Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson′s disease within the EPIC4ND cohort

被引:2
作者
Groeninger, Mareike [1 ]
Sabin, Jara [1 ,2 ]
Kaaks, Rudolf [1 ]
Amiano, Pilar [3 ,4 ]
Aune, Dagfinn [5 ,6 ,7 ]
Cabrera Castro, Natalia [8 ,9 ]
Guevara, Marcela [10 ,11 ,12 ]
Hansen, Johnni [13 ]
Homann, Jan [14 ]
Masala, Giovanna [15 ]
Nicolas, Genevieve [16 ]
Peters, Susan [17 ]
Sacerdote, Carlotta [18 ]
Sanchez, Maria-Jose [11 ,19 ,20 ]
De Magistris, Maria Santucci [21 ]
Sieri, Sabina [22 ]
Vermeulen, Roel [17 ,23 ]
Zhao, Yujia [17 ]
Lill, Christina M. [14 ,24 ]
Katzke, Verena A. [1 ]
机构
[1] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany
[2] Univ Clin Heidelberg Mannheim, Mannheim, Germany
[3] Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain
[4] Biogipuzkoa BioDonostia Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain
[5] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
[6] Norwegian Inst Publ Hlth, Canc Registry Norway, Dept Res, Oslo, Norway
[7] Oslo New Univ Coll, Dept Nutr, Oslo, Norway
[8] IMIB Arrixaca, Dept Epidemiol, Reg Hlth Council, Murcia, Spain
[9] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
[10] Inst Salud Publ & Laboral Navarra, Pamplona 31003, Spain
[11] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 28029, Spain
[12] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain
[13] Danish Canc Soc, Danish Canc Inst, Copenhagen, Denmark
[14] Univ Munster, Inst Epidemiol & Social Med, Munster, Germany
[15] Inst Canc Res Prevent & Clin Network ISPRO, Clin Epidemiol Unit, Florence, Italy
[16] Int Agcy Res Canc, Lyon, France
[17] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands
[18] Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy
[19] Escuela Andaluza Salud Publ EASP, Granada 18011, Spain
[20] Inst Invest Biosanitaria Ibs Granada, Granada 18012, Spain
[21] AOU Federico II, Naples, Italy
[22] Fdn IRCCS Ist Nazl Tumori, Milan, Italy
[23] Univ Med Ctr Utrecht, Utrecht, Netherlands
[24] Imperial Coll London, Ageing Epidemiol Res Unit, Sch Publ Hlth, London, England
基金
瑞典研究理事会; 英国医学研究理事会;
关键词
Dairy; Calcium; Vitamin D; Parkinson ' s disease; EPIC; CONSUMPTION; MIDLIFE; CANCER; FOODS;
D O I
10.1007/s10654-024-01183-9
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Literature indicates a potential association between dairy consumption and risk of Parkinson ' s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 participants of the EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Crude and multivariable-adjusted Cox proportional hazards models were employed to examine potential associations between baseline dietary intake of dairy, calcium and vitamin D with incident PD risk. No relationship was observed between dairy consumption (HR 1.07, 95% CI 0.82-1.39), individual dairy products (milk: HR 0.95, 95% CI 0.73-1.23; yogurt: HR 1.03, 95% CI 0.82-1.29; cheese: HR 1.13, 95% CI 0.85-1.51), or vitamin D (HR 1.08, 95% CI 0.80-1.45) with PD risk. However, we observed a risk-increasing association with higher calcium intakes (HR 1.33, 95% CI 1.00-1.78, p for trend=0.031), which was more pronounced in men (HR 1.50, 95% CI 1.00-2.25, p for trend=0.044) and in ever smokers (HR 1.64, 95% CI 1.06-2.53, p for trend=0.014). No compelling evidence was found for an association between dairy products or vitamin D intake and PD risk indicating a potentially limited relevance of dairy intake in PD risk than previously described. Our observations of a positive association between dietary calcium intake and PD risk in men and in ever smokers require further validation.
引用
收藏
页码:1251 / 1265
页数:15
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