Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut-liver axis

被引：1

作者：

Yang, Fan ^{[1
,2
]}

Ni, Beibei ^{[3
]}

Liang, Xiaoqi ^{[3
]}

He, Yizhan ^{[4
]}

Yuan, Chao ^{[5
]}

Chu, Jiajie ^{[3
]}

Huang, Yiju ^{[3
]}

Zhong, Hongyu ^{[3
]}

Yang, Li ^{[1
,2
]}

Lu, Jianxi ^{[1
,2
,3
]}

Xu, Yan ^{[1
,2
]}

Zhang, Qi ^{[1
,2
,3
]}

Chen, Wenjie ^{[1
,2
,3
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 3, Biotherapy Ctr, Guangzhou 510630, Peoples R China

[2] Sun Yat Sen Univ, Peoples Hosp Kashi 1, Affiliated Kashi Hosp, Xinjiang Stem Cells Special Plateau Dis Engn Techn, Kashi 844000, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 3, Cell Gene Therapy Translat Med Res Ctr, Guangzhou 510630, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 3, Zhaoqing Hosp, Dept Neurol, Zhaoqing 526070, Peoples R China

[5] Guangdong Prov Peoples Hosp, Gen Practice, Guangzhou 510080, Peoples R China

来源：

STEM CELL RESEARCH & THERAPY | 2025年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Extracellular vesicles; Mesenchymal stromal cells; Con A-induced hepatitis; Gut microbiota; FAILURE;

D O I：

10.1186/s13287-024-04013-7

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

BackgroundAs cell-free nanotherapeutics, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown potential therapeutic action against liver diseases. However, their effects on autoimmune hepatitis (AIH) are not yet well understood.Methods and resultsIn this study, we utilized a well-established concanavalin A (Con A)-induced fulminant hepatitis mouse model to investigate the effects of MSC-EVs on AIH. We found that MSC-EVs provide significant protection against Con A-induced hepatitis in C57BL/6 male mice, with their effectiveness being critically dependent on the gut microbiota. MSC-EVs modulate the composition of the gut microbiota, particularly by increasing the abundance of norank_f__Muribaculaceae, and impact liver metabolic profiles, leading to significant amelioration of liver injury. The identification of Acetyl-DL-Valine as a protective metabolite underscores the therapeutic potential of targeting gut-liver axis interactions in liver diseases.ConclusionOverall, our data demonstrate that MSC-EVs exhibit nanotherapeutic potential in Con A-induced hepatitis and provide new insights into the treatment of autoimmune hepatitis.

引用

页数：16

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