Advances in the mechanism of urinary proteins in calcium oxalate kidney stone formation

被引：2

作者：

Shi, Mingcheng ^{[1
]}

Su, Xiaozhe ^{[1
]}

Xiang, Heng ^{[1
]}

Song, Qianlin ^{[1
]}

Yang, Sixing ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Hubei, Peoples R China

来源：

UROLITHIASIS | 2025年 / 53卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Kidney stones; Calcium oxalate stones; Crystal; Matrix proteins; MATRIX GLA-PROTEIN; ALPHA-TRYPSIN-INHIBITOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ACID-RICH PROTEIN; RENAL EPITHELIAL-CELLS; TAMM-HORSFALL PROTEIN; PROTHROMBIN FRAGMENT 1; INDUCED UP-REGULATION; HUMAN SERUM-ALBUMIN; CRYSTAL-GROWTH;

D O I：

10.1007/s00240-025-01703-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Kidney stones are a common urological disease worldwide, imposing a significant burden on healthcare systems. Calcium oxalate stones are the predominant form of urinary calculi, with two main theoretical models explaining their pathogenesis: the fixed particle and free particle models. Regardless of the model, the formation of calcium oxalate kidney stones is inseparably linked to crystal nucleation, growth, aggregation, and adhesion in urine. Growing evidence highlights the significant role of urinary proteins, particularly matrix proteins, in the development of calcium oxalate stones. The review classifies urinary proteins impacting calcium oxalate stone formation into three groups: inhibitors, promoters, and dual-regulators, outlining their contributions to the formation process.

引用

页数：23

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