Divergent roles for propionate and butyrate in colorectal cancer epigenetics

被引：2

作者：

Cheong, Yuen Jian ^{[1
]}

Trefely, Sophie ^{[1
]}

机构：

[1] Babraham Inst, Epigenet & Signalling Programmes, Cambridge, England

来源：

NATURE METABOLISM | 2025年 / 7卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

HISTONE PROPIONYLATION; BUTYRYLATION; ACETYLATION; MICROBIOTA; REVEALS;

D O I：

10.1038/s42255-024-01186-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intestinal short chain fatty acids (SCFAs) propionate and butyrate directly contribute to epigenetic regulation by supplying precursor molecules for histone lysine modifications. Nshanian et al. examine how propionate and butyrate supplementation affects gene regulation in colorectal cancer (CRC) cells, revealing distinct effects for each. Comparing normal cells with cancer cells shows context-dependent responses that might inform metabolic interventions.

引用

页码：11 / 13

页数：3

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