Impact of COVID-19 infection on Kawasaki disease and immune status in children

被引：0

作者：

Gao, Lichao ^{[1
]}

Xu, Zhufei ^{[2
]}

Hu, Jian ^{[1
]}

Zhang, Qing ^{[1
]}

Fu, Songling ^{[1
]}

Wang, Wei ^{[1
]}

Xie, Chunhong ^{[1
]}

Zhang, Yiying ^{[1
]}

Wang, Yujia ^{[1
]}

Gong, Fangqi ^{[1
]}

机构：

[1] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med,Dept Cardiol, 3333 Binsheng Rd, Hangzhou 310052, Peoples R China

[2] Zhejiang Univ, Sch Med, Childrens Hosp, Dept Pulmonol,Natl Clin Res Ctr Child Hlth, Hangzhou, Peoples R China

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Kawasaki disease; COVID-19; Immunity; IVIG resistance; Child; INTRAVENOUS IMMUNOGLOBULIN; TREATMENT RESPONSE; CELLS;

D O I：

10.1038/s41598-025-91042-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Patients infected with SARS-CoV-2 may experience acute and long-term immune disorders. Immunological factors are thought to play an important role in Kawasaki disease. To analyze the impact of COVID-19 infection on Kawasaki disease, this study retrospectively analyzed 161 children with Kawasaki disease onset during the COVID-19 pandemic. The proportion of IVIG-Resistant individuals and the rate of corticosteroid use in the 1-7 weeks from COVID-19 infection to Kawasaki disease onset were higher than that of the noninfected group, even after excluding suspected cases of multiple system inflammatory syndrome. Compared to the noninfected group, the level of CD4 was lower, and the levels of CD3-CD16+CD56+, complement C4, TNF-alpha, and IFN-gamma were higher in the 1-7 weeks after COVID-19 infection. In conclusion, the risk of IVIG resistance was significantly increased in children with Kawasaki disease onset 1-7 weeks after COVID-19 infection, which may be related to the long-term impact of COVID-19 on immunity.

引用

页数：10

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