A New Amide from the Fermentation of Fusarium sp. SFS-G3 and Cytotoxic Activities

被引：0

作者：

Yang, Min ^{[1
,2
]}

Ma, Yue-Yu ^{[1
,2
]}

Xiong, Rui-Feng ^{[1
,2
]}

Dong, Miao ^{[1
,2
]}

Hu, Qiu-Fen ^{[1
,2
]}

Li, Yin-Ke ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China

[2] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2024年 / 60卷 / 06期

关键词：

Fusarium sp; amide; cytotoxic activities; ELUCIDATION; DERIVATIVES;

D O I：

10.1007/s10600-024-04524-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-(5-((3E,5E)-10-Acetoxy-5,7,9,11-tetramethyltrideca-3,5-dien-1-yl)-2-oxotetrahydrofuran-3-yl)acetamide (1), a new amide compound, and five known ones (2-6) were isolated from the EtOH extract of the solid culture of Fusarium sp. Their structures were determined by means of extensive 1D and 2D NMR techniques, as well as comparison with literature values. Additionally, compounds 1-6 were tested for their cytotoxic activities. The results showed that compounds 2, 3, 6 exhibited cytotoxic activities against five human cancer cell lines with IC50 values ranging from 2.088 to 26.40 mu M.

引用

页码：1080 / 1083

页数：4

共 15 条

[1] SYNTHESIS OF SOME GAMMA-SUBSTITUTED ALPHA-AMINO GAMMA-LACTONES [J].