Clinical observation of esculin and digitalisglycosides eye drops with 0.3% sodium hyaluronate eye drops for dry eye disease: a randomized controlled trial

被引：0
作者：
Wang, Yinghui [1 ]
Yuan, Jiahao [2 ]
Wen, Ya [1 ]
Li, Siyuan [1 ]
Tian, Lei [1 ]
Jie, Ying [1 ]
机构：
[1] Capital Med Univ, Beijing Tongren Hosp, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol,Beijing Tongren Eye Ctr, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China
[2] Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, State Key Lab Digest Hlth,Liver Res Ctr, 95 Yongan Rd, Beijing 100050, Peoples R China
来源：
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Dry eye disease; Esculin; Digitalisglycosides; 0.3% sodium hyaluronate; DIGOXIN; CCR5;
D O I：
10.1038/s41598-025-90074-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Dry eye disease (DED) is a common ocular surface disorder. Esculin and digitalis possess anti-inflammatory and anti-oxidant properties, which may benefit patients with DED. This study aimed to assess the therapeutic efficacy of esculin and digitalis glycosides (EAD) eye drops, either alone or in combination with 0.3% sodium hyaluronate (SH) eye drops, in treating DED. In this randomized controlled trial, 78 participants with DED (78 eyes) were included and divided into three groups: Group A received 0.3% SH, Group B received EAD, and Group C received 0.3% SH combined with EAD eye drops for 4 weeks. The efficacy of the treatments was assessed at 2 and 4 weeks using the Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), Schirmer I test (SIt), and corneal fluorescein staining (CFS) as primary evaluation metrics. After 4 weeks of treatment, Group A showed a decrease in OSDI and an increase in SIT (p < 0.05). Group B showed a decrease in OSDI score (P < 0.05) and a significant improvement in SIt (P < 0.01). Group C demonstrated a significant increase in both TBUT and SIt values at the 2-week mark. Improvements were noted across all parameters, including OSDI score, TBUT, SIt, and CFS score after 4 weeks of treatment (P < 0.05). The total effective rate for participants in Group C was 88.46%, significantly higher than Group A's rate of 65.38% (P < 0.05). In conclusion, the combination of EAD eye drops with 0.3% SH eye drops proved more effective than either treatment alone.
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页数：9
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