External validation of the ICU-CARB score to predict carbapenem-resistant gram-negative bacteria carriage in critically ill patients upon ICU admission: a multicenter analysis

被引:0
作者
Wu, Tong [1 ]
Wang, Xiaoli [1 ]
Shen, Ziyun [2 ]
Zhang, Zhongwei [3 ]
Liu, Yuhao [4 ]
Fang, Rong [5 ]
Wang, Qian [5 ]
Wang, Sheng [6 ]
Zhou, Quanhong [3 ]
Qu, Hongping [1 ,7 ]
Dai, Yunqi [1 ]
Tan, Ruoming [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Crit Care Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
[2] Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Dept Crit Care, Shanghai Peoples Hosp Affiliated 6, Sch Med, Shanghai, Peoples R China
[4] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Crit Care Med, Shanghai, Peoples R China
[5] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Emergency, Shanghai, Peoples R China
[6] Tongji Univ, Tongji Hosp, Intens Care Med Ctr, Sch Med, Shanghai 200065, Peoples R China
[7] Shanghai Jiao Tong Univ, Coll Hlth Sci & Technol, Sch Med, Shanghai, Peoples R China
来源
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL | 2024年 / 13卷 / 01期
基金
中国国家自然科学基金;
关键词
Carbapenem-resistant gram-negative bacteria; Intensive care unit; External validation; Precaution; Predictive analytics; RISK-FACTORS; ENTEROBACTERIACEAE; COLONIZATION; PROGNOSIS; MORTALITY; OUTCOMES; MODEL;
D O I
10.1186/s13756-024-01509-y
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Recognition of carbapenem-resistant gram-negative bacteria (CR-GNB) carriage is frequently delayed, which increases the risk of subsequent infection and transmission. Previously, we developed a scoring system to identify CR-GNB carriage upon intensive care unit (ICU) admission. Although the ICU-CARB score showed satisfactory performance, it has not been externally validated. In this study, therefore, we externally validated the ICU-CARB score. Methods In the previous article, we introduced a risk-scoring system that incorporated seven key variables: neurological disease, high-risk department history, length of stay >= 14 days, ICU history, invasive mechanical ventilation, gastrointestinal tube placement, and carbapenem usage. To externally validate the ICU-CARB score, we conducted a study involving patients admitted to the ICUs of four tertiary hospitals between January 2021 and December 2023. Patients from three hospitals were grouped into Cohort I (n = 815) and those from the fourth hospital into Cohort II (n = 1602). Model calibration, discrimination, and performance were then assessed. Results A total of 2417 patients were included, among which 289 (12%) carried CR-GNB upon ICU admission. Neurological disease, high-risk department history and length of stay >= 14 days were still 3 most important contributing factors in the scoring system. The ICU-CARB score exhibited high calibration, with an area under the receiver operating characteristic curve of 0.825 (95% confidence interval [CI], 0.778-0.873) for Cohort I and 0.823 (95% CI, 0.791-0.855) for Cohort II. The ICU-CARB score showed a highly positive association with CR-GNB carriage in both cohort I (C = 0.315; P < 0.001) and Cohort II (C = 0.381; P < 0.001). Conclusions Despite differences in patient population characteristics, the ICU-CARB score for CR-GNB carriage upon ICU admission exhibited good discrimination in external validation, supporting its potential generalizability to other ICU settings.
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页数:10
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