Gender differences in clinical characteristics and influencing factors of suicide attempts in first-episode and drug-naïve major depressive disorder patients with comorbid metabolic syndrome

被引:0
作者
Sun, Ping [1 ]
Huang, Yingying [2 ]
Yu, Hui [1 ]
Wu, Xiaohui [3 ]
Chen, Jun [3 ]
Fang, Yiru [3 ,4 ,5 ]
Zhang, Xiangyang [6 ,7 ]
机构
[1] Qingdao Mental Hlth Ctr, Qingdao 266034, Shandong, Peoples R China
[2] Nanjing Univ, Nanjing Brain Hosp, Clin Teaching Hosp, Med Sch, Nanjing 210093, Peoples R China
[3] Shanghai Jiao Tong Univ, Clin Res Ctr, Shanghai Mental Hlth Ctr, Div Mood Disorders,Sch Med, Shanghai 200030, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Psychiat & Affect Disorders Ctr, Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China
[5] Shanghai Key Lab Psychot disorders, Shanghai 201108, Peoples R China
[6] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
[7] Univ Chinese Acad Sci, Dept Psychol, Beijing 100083, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
Major depressive disorder; Metabolic syndrome; Suicide attempts; Gender difference; MENTAL-DISORDERS; SEX-DIFFERENCES; RATING-SCALE; RISK-FACTORS; PREVALENCE; SYMPTOMS; METAANALYSIS; ASSOCIATION; ANXIETY; ADULTS;
D O I
10.1186/s12888-024-06256-3
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
BackgroundsPatients with major depressive disorder (MDD) have a high rate of metabolic syndrome (MetS), which could worsen disease progression. One of the most serious progressions in MDD is suicide attempts (SAs). Previous studies have found gender differences in MetS and SAs among MDD patients respectively. Therefore, we aimed to explore gender differences of SAs in first-episode and drug-na & iuml;ve (FEDN) MDD patients with comorbid MetS.Methods1718 outpatients with FEDN MDD were recruited. Depression, anxiety and psychotic symptoms were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Blood sugar, blood fat, blood pressure and body mass index (BMI) were measured to evaluate MetS.Results34.4% patients with FEDN MDD were diagnosed as MetS and those subjects with or without MetS differed in the distribution of SAs and gender. In MetS subgroup, 29.5% and 29.7% of male and female subjects had SAs respectively, without significant differences. However, compared with non-suicide attempters, suicide attempters had higher level of blood pressure in female subjects, while there are no differences in any clinical variables in male subjects. Additionally, the influencing factors for SAs differed by gender. The HAMA scores and BMI were variables associated with SAs in male patients while HAMA scores, marital status and systolic blood pressure (SBP) were associated with SAs in female patients. Furthermore, the receiver operating characteristics (ROC) curves, demonstrating the combination all influencing factors by gender, showed good performance and model accuracy.ConclusionsIn FEDN MDD patients with comorbid MetS, there were no gender differences in SAs. However, clinical characteristics and influencing factors of SAs differed in different gender groups.
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页数:13
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