Updates in Diagnosis and Treatment of Immune Checkpoint Inhibitor Myocarditis

被引：0

作者：

Hachem, Anthony M. ^{[1
]}

Desai, Aditya ^{[1
,2
]}

Beinart, Noah ^{[1
]}

Ostos-Mendoza, Keila C. ^{[1
,3
]}

Rodriguez, Ana Sofia Lopez ^{[1
,3
]}

Derby, Regina Diaz de Leon ^{[1
,3
]}

Ebrahimi, Sara ^{[1
]}

Palaskas, Nicolas L. ^{[1
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Lakeside Sch, Seattle, WA USA

[3] Tecnol Monterrey, Sch Med & Hlth Sci, Monterrey 64710, Nuevo Leon, Mexico

[4] Univ Texas MD Anderson Canc Ctr, Dept Cardiol, 1515 Holcombe Blvd,Unit 1451, Houston, TX 77030 USA

来源：

CURRENT CARDIOLOGY REPORTS | 2025年 / 27卷 / 01期

关键词：

Immune checkpoint inhibitors; Myocarditis; Immunotherapy; Diagnosis; Treatment; MAGNETIC-RESONANCE; CANCER; EVENTS; TOCILIZUMAB; MANAGEMENT; ABATACEPT; THERAPY;

D O I：

10.1007/s11886-025-02232-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review To provide an update on the literature regarding diagnosis and management of immune checkpoint inhibitor myocarditis. Recent Findings The diagnosis of immune checkpoint inhibitor myocarditis has evolved to include more reliance on performing endomyocardial biopsy to clarify the diagnosis in selected cases. Additionally, there is recognition of a spectrum of disease both clinically and on endomyocardial biopsy suggesting that there is a range of severity from mild to fulminant. The treatment of immune checkpoint inhibitor myocarditis is shifting towards increased use of additional immunosuppressive medications as steroid sparing agents. There are increased studies including two randomized controlled trials evaluating abatacept in the treatment of immune checkpoint inhibitor myocarditis. Summary This review summarizes the latest literature regarding diagnosis and management of immune checkpoint inhibitor myocarditis and provides our experience and approach to this rare but potentially fatal condition.

引用

页数：11

共 60 条

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