A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment

被引：1

作者：

Huang, Aoling ^{[1
]}

Xue, Haochen ^{[1
]}

Xie, Ting ^{[1
]}

Xiang, Lingyan ^{[1
]}

Chen, Zhengzhuo ^{[1
]}

Ma, Aolong ^{[1
]}

Yan, Honglin ^{[1
]}

Yuan, Jingping ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Pathol, 238 Jiefang-Rd, Wuhan 430060, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2025年 / 23卷 / 01期

关键词：

Mitochondria; Mitochondrial dynamics; Breast cancer; Mitochondrial metabolism; Apoptosis; OXIDATIVE-PHOSPHORYLATION; CELLS; DNA; METASTASIS; METABOLISM; RECURRENCE; ACTIVATION; PHENOTYPES; MUTATIONS; SERUM;

D O I：

10.1186/s12967-025-06077-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms. Mitochondria, highly dynamic intracellular organelles, play a pivotal role in maintaining cellular energy metabolism. Altered mitochondrial function plays a critical role in various diseases, and recent studies have elucidated its pathophysiological mechanisms in breast carcinogenesis. This review explores the role of mitochondrial dysfunction in breast cancer pathogenesis and assesses potential mitochondria-targeted therapies.

引用

页数：14

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