Comparison of CT findings between basaloid squamous cell carcinoma and non-basaloid squamous cell carcinoma of the lung

被引：0
作者：
Seo, Yujin [1 ,2 ]
Cha, Yoon Ki [1 ,2 ]
Kim, Chu Hyun [3 ]
Chung, Myung Jin [1 ,2 ]
Kim, Tae Jung [1 ,2 ]
Han, Joungho [4 ]
Lee, Junghee [5 ]
Yoon, Hyun Jung [6 ]
机构：
[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiol, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea
[2] Sungkyunkwan Univ, Ctr Imaging Sci, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea
[3] Samsung Med Ctr, Ctr Hlth Promot, Seoul, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea
[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Thorac & Cardiovasc Surg, Seoul, South Korea
[6] Vet Hlth Serv Med Ctr, Dept Radiol, Seoul, South Korea
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
Lung neoplasms; Squamous cell carcinoma; Computed tomography; HEALTH-ORGANIZATION CLASSIFICATION; CANCER; CAVITATION; EXPRESSION; TUMOR;
D O I：
10.1038/s41598-024-82896-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This study aimed to compare computed tomography (CT) findings between basaloid lung squamous cell carcinoma (SCC) and non-basaloid SCC. From July 2003 to April 2021, 39 patients with surgically proven basaloid SCC were identified. For comparison, 161 patients with surgically proven non-basaloid SCC from June 2018 to January 2019 were selected consecutively. Clinical features, demographic characteristics, and CT findings were compared using chi-square test or Fisher's exact test except for differences in means for which Student's t-test was used. Additionally, Mantel-Haenszel test was performed to control the confounding of the presence of cavitation between basaloid and non-basaloid SCCs with tumors stratified by clinical T staging. Compared with patients with non-basaloid SCC, patients with basaloid SCC had significantly (p < 0.001) more frequent respiratory symptoms at the time of presentation. Regarding CT findings, endobronchial tumor growth and obstructive pneumonia or atelectasis were significantly (p = 0.028 and p = 0.028, respectively) more common in basaloid SCC than in non-basaloid SCC. Compared with non-basaloid SCC, cavitation was absent (p = 0.005) and internal profuse necrosis was significantly (p = 0.022) less frequent in basaloid SCC. Furthermore, presence of cavitation consistently showed significant difference after the tumors stratified based on clinical T staging (p = 0.015). Basaloid SCC had some CT findings different from non-basaloid SCC. Basaloid SCC showed more frequent endobronchial tumor growth with obstructive pneumonia or atelectasis. Internal profuse necrosis was less common, and cavitation was absent in basaloid SCC compared to non-basaloid SCC.
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页数：9
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