Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study

被引：1

作者：

Weide Lin ^{[1
]}

Bixia Lin ^{[2
]}

Junfan Chen ^{[1
]}

Renwei Li ^{[1
]}

Yaohua Yu ^{[1
]}

Shiqing Huang ^{[1
]}

Shurong Li ^{[1
]}

Jing Lin ^{[1
]}

机构：

[1] Department of Anesthesiology, The First Hospital of Putian City, Putian

[2] Department of Ultrasonography, The First Hospital of Putian City, Nanmen West Road, Chengxiang District, Putian

来源：

Scientific Reports | / 14卷 / 1期

关键词：

30-day mortality; Retrospective cohort study; Sepsis; Unintentional weight loss;

D O I：

10.1038/s41598-024-83260-3

中图分类号：

学科分类号：

摘要：

This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, involving 1842 sepsis patients in the ICU. We utilized multivariate Cox regression analysis to evaluate the association between unintentional weight loss and the risk of 30-day mortality. In addition, we conducted stratified and interaction analyses to determine the consistency of this association across various demographic and clinical subgroups. Out of the 1842 patients, 19.2% (354) died within 30 days. The fully adjusted multivariate Cox regression model revealed that for every one-unit decrease in body weight, the risk of death increased by 58% (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 1.20–2.07). Unintentional weight loss was found to be positively correlated with 30-day mortality. Subgroup analysis yielded consistent results across all groups. Unintentional weight loss was positively associated with a greater risk of mortality in critically ill patients with sepsis in the ICU. © The Author(s) 2024.

引用

共 41 条

[1] Weng L., Zeng X.-Y., Et al., Sepsis-related mortality in China: A descriptive analysis, Intensive Care Med, 44, 7, pp. 1071-1080, (2018)
[2] Reinhart K., Daniels R., Kissoon N., Machado F.R., Schachter R.D., Finfer S., Recognizing sepsis as a global health priority—A WHO resolution, N. Engl. J. Med, 377, 5, pp. 414-417, (2017)
[3] Fleischmann C., Scherag A., Adhikari N.K.J., Et al., Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations, Am. J. Respir. Crit. Care Med, 193, 3, pp. 259-272, (2016)
[4] Taniguchi L.U., Bierrenbach A.L., Toscano C.M., Schettino G.P., Azevedo L.C., Sepsis-related deaths in Brazil: An analysis of the national mortality registry from 2002 to 2010, Crit. Care, 18, 6, (2014)
[5] Singer M., Deutschman C.S., Seymour C.W., Et al., The third international consensus definitions for sepsis and septic shock (Sepsis-3), JAMA, 315, 8, (2016)
[6] Seymour C.W., Rea T.D., Kahn J.M., Walkey A.J., Yealy D.M., Angus D.C., Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome, Am. J. Respir. Crit. Care Med, 186, 12, pp. 1264-1271, (2012)
[7] Rhee C., Dantes R., Epstein L., Et al., Incidence and trends of sepsis in us hospitals using clinical vs claims data, 2009–2014, JAMA, 318, 13, (2017)
[8] Cecconi M., Evans L., Levy M., Rhodes A., Sepsis and septic shock, Lancet, 392, pp. 75-87, (2018)
[9] Rhee C., Jones T.M., Hamad Y., Et al., Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals, JAMA Netw. Open, 2, 2, (2019)
[10] Thirunavukarasu P., Sanghera S., Singla S., Attwood K., Nurkin S., Pre-operative unintentional weight loss as a risk factor for surgical outcomes after elective surgery in patients with disseminated cancer, Int. J. Surg, 18, pp. 7-13, (2015)

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