GD3 ganglioside checkpoints in immune surveillance of senescent cells: Immune surveillance

被引：0
|
作者：
Majewska, Julia [1 ]
Krizhanovsky, Valery [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel
来源：
NATURE AGING | 2025年 / 5卷 / 02期
基金：
欧洲研究理事会; 以色列科学基金会;
关键词：
D O I：
10.1038/s43587-025-00803-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.
引用
收藏
页码：182 / 183
页数：2
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