Impact of SARS-CoV-2 variants on viral infectivity and the role of the renin-angiotensin-aldosterone system

被引：0
作者：
Matsuzawa, Yasushi [1 ]
Tsujita, Kenichi [1 ]
机构：
[1] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto, Japan
来源：
HYPERTENSION RESEARCH | 2025年
关键词：
COVID-19; RAAS inhibitor; Omicron;
D O I：
10.1038/s41440-025-02115-0
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Balance between Protective vs. Exacerbating Effects of ACEIs and ARBs in Omicron Variant Infections. The spike protein on the surface of the Omicron variant has a high affinity for ACE2, making it more prone to enter cells and induce ACE2 downregulation. Therefore, the effects of ACEIs and ARBs on Omicron variant infections may differ from those of the previous variants. The current study demonstrates that ACEIs and ARBs do not aggravate or prolong COVID-19 due to Omicron variant infections.[graphic not available: see fulltext]
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页码：1636 / 1638
页数：3
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