Pediatric MASLD: current understanding and practical approach

被引:3
作者
Stroes, Anne-Sophie R. [1 ]
Vos, Miriam [2 ,3 ]
Benninga, Marc A. [1 ]
Koot, Bart G. P. [1 ]
机构
[1] Univ Amsterdam, Emma Childrens Hosp, Dept Pediat Gastroenterol, Amsterdam UMC, Amsterdam, Netherlands
[2] Emory Univ, Dept Pediat, Div Pediat Gastroenterol Hepatol & Nutr, Sch Med, Atlanta, GA USA
[3] Childrens Healthcare Atlanta, Atlanta, GA USA
关键词
MASLD; Obesity; Children; MASH; FATTY LIVER-DISEASE; MAGNETIC-RESONANCE ELASTOGRAPHY; OBSTRUCTIVE SLEEP-APNEA; LIFE-STYLE INTERVENTION; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; OBESE CHILDREN; VITAMIN-E; TRANSIENT ELASTOGRAPHY; FIBROSIS STAGE;
D O I
10.1007/s00431-024-05848-1
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease in children in industrialized countries mainly due to the rise in obesity and overweight. Besides risk of progressive liver damage, MASLD also carries an increased risk of extra-hepatic morbidity, most importantly type 2 diabetes mellitus and cardiovascular disease. Important challenges remain in the prevention, detection, and treatment of this prevalent disorder. This review outlines the epidemiology and risk factors of MASLD and provides an approach to screening, diagnosis, and treatment based on current best available evidence and expert opinion. What is known: center dot NAFLD/MASLD is a common disorder in children strongly related to obesity/overweight and insulin resistance. center dot This silent disorder is underdiagnosed due to lack of awareness and lack of simple diagnostic criteria. What is new: center dot New diagnostic criteria have transformed NAFLD/MASLD from a diagnosis of exclusion to a positive diagnosis with simple criteria. center dot Effective treatments are emerging for adults and will likely become available for children. center dot Identifying children with NAFLD/MASLD has become even more important due to this new treatment perspective.
引用
收藏
页数:12
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