Fabrication of lipid-modified drug nanocrystals loaded injectable hydrogel for breast cancer therapy

被引：0

作者：

Kumar, Manish ^{[1
,2
]}

Jha, Abhishek ^{[1
,3
]}

Goswami, Pooja ^{[4
]}

Srivastava, Ritika ^{[1
]}

Manjit, Manjit ^{[1
]}

Bharti, Kanchan ^{[1
]}

Koch, Biplob ^{[4
]}

Mishra, Brahmeshwar ^{[1
]}

机构：

[1] Indian Inst Technol BHU, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India

[2] Amity Univ, Amity Inst Pharm, Greater Noida 201308, Uttar Pradesh, India

[3] Dr DY Patil Inst Pharmaceut Sci & Res, Dept Pharmaceut, Pune 411018, Maharashtra, India

[4] Banaras Hindu Univ, Inst Sci, Dept Zool, Genotoxicol & Canc Biol Lab, Varanasi 221005, Uttar Pradesh, India

来源：

DISCOVER NANO | 2025年 / 20卷 / 01期

关键词：

Nanocrystals; Hydrogel; Implant; Drug delivery; Breast cancer; PACLITAXEL; ANTITUMOR; RELEASE;

D O I：

10.1186/s11671-025-04195-w

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The current study includes the design of soluplus stabilized, lipid-coated, and fucoidan-oleylamine conjugate modified paclitaxel nanocrystals. The nanocrystals (Lipid-NCs) were about 100 nm, homogeneous, stable and showed improved drug release compared to pure PTX. The nanocrystals were subsequently loaded in an in situ gel-forming hydrogel for the intratumoral injection. The resulting hydrogel exhibited a sol-form at the lower temperature of 2-8 degrees C while converted to a gel-form at the body temperature. The injectable hydrogel had a reasonable viscosity, an acceptable pH, good syringeability, and a quick sol-gel transition. The hydrogel demonstrated high payload potential, homogeneous distribution, and controlled long-term drug release. In vivo studies revealed the higher efficacy of Lipid-NCs hydrogel in tumor inhibition while avoiding systemic toxicity, compared to pure PTX-loaded hydrogel and intravenously administered PTX. In conclusion, nanocrystal-loaded hydrogel is a promising localized drug delivery system for breast cancer therapy.

引用

页数：19

共 39 条

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