Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance

被引：0

作者：

Ngwana-Joseph, Gabrielle C. ^{[1
]}

Phelan, Jody E. ^{[1
]}

Manko, Emilia ^{[1
]}

Dombrowski, Jamille G. ^{[1
,2
]}

Santos, Simone da Silva

Suarez-Mutis, Martha ^{[3
]}

Velez-Tobon, Gabriel ^{[4
]}

Tobon Castano, Alberto ^{[4
]}

Machado, Ricardo Luiz Dantas ^{[5
]}

Marinho, Claudio R. F. ^{[2
]}

Nolder, Debbie ^{[6
]}

Nosten, Francois ^{[7
,8
]}

Sutherland, Colin J. ^{[1
,6
]}

Campino, Susana ^{[1
]}

Clark, Taane G. ^{[1
,9
]}

机构：

[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect Biol, London, England

[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, Brazil

[3] Oswaldo Cruz Fdn FIOCRUZ, Rio De Janeiro, Brazil

[4] Univ Antioquia, Fac Med, Grp Malaria, Antioquia, Colombia

[5] Univ Fed Fluminense, Ctr Invest Microrganismos CIM, Dept Microbiol & Parasitol, Niteroi, Brazil

[6] UK Hlth Secur Agcy, London Sch Hyg & Trop Med, Malaria Reference Lab, London, England

[7] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[8] Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand

[9] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London, England

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

巴西圣保罗研究基金会; 英国生物技术与生命科学研究理事会; 英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISMS; POSITIVE SELECTION; P; FALCIPARUM; R PACKAGE; EX-VIVO; CHLOROQUINE; PAPUA; ASSOCIATION; PIPERAQUINE; FRAMEWORK;

D O I：

10.1038/s41467-024-54964-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P. vivax isolates across 29 endemic countries, detailing population structure, patterns of relatedness, selection, and resistance profiling, providing insights into potential drivers of CQR. Selective sweeps in a locus proximal to pvmdr1, a putative marker for CQR, along with transcriptional regulation genes, distinguish isolates from Indonesia from those in regions where chloroquine remains highly effective. In 106 isolates from Indonesian Papua, the epicentre of CQR, we observe an increasing prevalence of novel SNPs in the candidate resistance gene pvmrp1 since the introduction of dihydroartemisinin-piperaquine. Overall, we provide novel markers for resistance surveillance, supported by evidence of regions under recent directional selection and temporal analysis in this continually evolving parasite.

引用

页数：13

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