Topical 5-aminolevulinic acid-mediated photodynamic therapy versus loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia

被引：0

作者：

Yidi Liu ^{[1
]}

Yi Li ^{[1
]}

Huan Wu ^{[2
]}

Ying Wang ^{[3
]}

Jing Zeng ^{[2
]}

Hui Li ^{[2
]}

Haixia Qiu ^{[4
]}

Ying Gu ^{[2
]}

机构：

[1] Department of Laser Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing

[2] Medical School of Chinese PLA, Beijing

[3] Medical Big Data Center, Chinese PLA General Hospital, Beijing

[4] Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing

[5] Precision Laser Medical Diagnosis and Treatment Innovation Unit, Chinese Academy of Medical Sciences, Beijing

来源：

Holistic Integrative Oncology | / 3卷 / 1期

关键词：

5-aminolevulinic acid; Cervical intraepithelial neoplasia; Human papillomavirus; Loop electrosurgical excision procedure; Photodynamic therapy; Squamous intraepithelial lesion;

D O I：

10.1007/s44178-024-00127-3

中图分类号：

学科分类号：

摘要：

Objective: To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) and loop electrosurgical excision procedure (LEEP) among patients with cervical intraepithelial neoplasia (CIN). Methods: We retrospectively identified patients who underwent either 5-ALA PDT or LEEP from Sep. 2012 to Dec. 2019 in Chinese PLA general hospital. Patients’ outcomes were compared according to the HPV genotyping, cytological tests within 3–6-month follow-up post-treatment, the pathological examination would be performed if the cytological results indicated the risk of CIN. Propensity score matching (PSM) was adapted to pair the baseline. Complete remission (CR), partial remission (PR) and the remission rate of HPV infections were used to evaluate the efficacy of 5-ALA PDT versus LEEP. Results: In total, 30 pairs were matched as the matching tolerance was set as 0.03. There was no significant difference about the CR and PR between 5-ALA PDT and LEEP group (73.33% vs 84.00%, P = 0.340; 3.33% vs 4.00%, P = 1.000). Among different CIN group, there was no statistic difference between 5-ALA PDT and LEEP. Moreover, in terms of HPV remission rate, 5-ALA PDT showed the same efficacy as LEEP (59.26% vs 53.85%, P = 0.691). Conclusions: In essence, topical 5-ALA PDT emerges as a non-invasive, repeatable procedure with minimal side effects for cervical lesions, preserving cervical structure. Overall, the efficacy of 5-ALA PDT is comparable to LEEP in achieving successful outcomes. © The Author(s) 2024.

引用

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