Effect of polyunsaturated fatty acids intake on the occurrence of current asthma among children and adolescents exposed to tobacco smoke: NHANES 2007-2018

被引:0
作者
Wang, Chunyan [1 ]
Wang, Li [2 ]
Ding, Wanling [3 ]
Zhao, Feng [4 ]
Hou, Guoqiang [1 ]
机构
[1] Changzhi Maternal & Child Hlth Care Hosp, Dept Emergency, 48 Weiyuanmen Middle Rd, Changzhi 046000, Shanxi, Peoples R China
[2] Changzhi Maternal & Child Hlth Care Hosp, Dept Neonatol, Changzhi 046000, Shanxi, Peoples R China
[3] Changzhi Maternal & Child Hlth Care Hosp, Dept Pediat Resp, Changzhi 046000, Shanxi, Peoples R China
[4] Changzhi Maternal & Child Hlth Care Hosp, Dept Pediat Digest, Changzhi 046000, Shanxi, Peoples R China
关键词
Polyunsaturated fatty acids; Omega-3; Omega-6; Current asthma; Tobacco smoke exposure; NHANES database; COTININE; OMEGA-3-FATTY-ACIDS; SEVERITY;
D O I
10.1186/s41043-024-00663-8
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background Asthma is an airway inflammatory disease driven by multiple factors with a high incidence in children and adolescents. Environmental tobacco smoke exposure (TSE) and diet are inducing factors for asthma. The potential of omega-3 polyunsaturated fatty acids (PUFAs) to alleviate asthma symptoms by their anti-inflammatory effects has been explored. However, to date, no studies have explored the effect of dietary PUFAs intake on the asthma in children and adolescents exposed to tobacco smoke. Objective We aimed to examine the effect of dietary PUFAs intake on the current asthma in children and adolescents exposed to tobacco smoke. Methods Data of this cross-sectional were extracted from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Children and adolescents with serum cotinine concentration >= 0.05 ng/mL were defined to exposed to tobacco smoke. Dietary PUFAs intake information were obtained from 24 h recall interview. The weighted univariate and multivariate were utilized to explore the effect of PUFAs on the association of asthma and TSE, with adjusted odds ratios (AORs) and 95% confidence intervals (CIs). These moderating effects were further explored based on the age, gender and body mass index (BMI) and sedentary time. Results Totally, 7981 eligible children and adolescents were included, with the mean age of 11.96 +/- 0.06 years old. Of whom, 1.024 (12.83%) had current asthma. After adjusted all covariates, we found children and adolescents with TSE had high occurrence of current asthma (AOR = 1.2, 95% CI 1.03-1.63); We also found omega-3 PUFAs intake (P for interaction = 0.010), not omega-6 PUFAs (P for interaction = 0.546), has a moderating effect on the association of TSE and current asthma. Moreover, we further observed that children and adolescents with TSE and low omega-3 PUFAs intake had high occurrence of current asthma (AOR = 1.58, 95% CI 1.19-2.10), while no significant association was found in children and adolescents with high omega-3 PUFAs intake (all P > 0.05). This moderating effect was more prominent in children and adolescents aged <= 12 years old (AOR = 1.62, 95% CI 1.06-2.47), girls (AOR = 2.14, 95% CI 1.15-3.98), overweight (AOR = 1.87, 95% CI 1.01-3.47) and sedentary time > 6 h (AOR = 1.96, 95% CI 1.00-3.86). Conclusion We found dietary omega-3 PUFAs plays a moderating effect on the association of asthma and TSE in children and adolescents, especially in children and adolescents aged <= 12 years, girls, overweight or sedentary time > 6 h. This moderating effect suggested higher omega-3 intake has potential benefits in decreasing the occurrence of asthma in children and adolescents who exposed to tobacco smoke.
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共 36 条
  • [1] Akinbami LJ., 2022, Vital Health Stat, V1, P1, DOI DOI 10.15620/CDC:115434
  • [2] Inhaled Corticosteroids and Endocrine Effects in Childhood
    Allen, David B.
    [J]. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2020, 49 (04) : 651 - +
  • [3] Worldwide trends in the burden of asthma symptoms in school-aged children: Global Asthma Network Phase I cross-sectional study
    Asher, M. Innes
    Rutter, Charlotte E.
    Bissell, K.
    Chiang, Chen-Yuan
    El Sony, Asma
    Ellwood, Eamon
    Ellwood, Philippa
    Garcia-Marcos, Luis
    Marks, Guy B.
    Morales, Eva
    Mortimer, Kevin
    Perez-Fernandez, Virginia
    Robertson, Steven
    Silverwood, Richard J.
    Strachan, David P.
    Pearce, Neil
    [J]. LANCET, 2021, 398 (10311) : 1569 - 1580
  • [4] Benowitz NL, 2018, CANCER EPIDEM BIOMAR, V27, P254, DOI [10.1158/1055-9965.EPI-17-0671, 10.1158/1055-9965.epi-17-0671]
  • [5] Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children
    Brigham, Emily P.
    Woo, Han
    McCormack, Meredith
    Rice, Jessica
    Koehler, Kirsten
    Vulcain, Tristan
    Wu, Tianshi
    Koch, Abigail
    Sharma, Sangita
    Kolandooz, Fariba
    Bose, Sonali
    Hanson, Corrine
    Romero, Karina
    Diette, Gregory
    Hansel, Nadia N.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199 (12) : 1478 - 1486
  • [6] Dietary prevention strategies for childhood asthma
    Brustad, Nicklas
    Bonnelykke, Klaus
    Chawes, Bo
    [J]. PEDIATRIC ALLERGY AND IMMUNOLOGY, 2023, 34 (07)
  • [7] Omega-3 fatty acids and inflammatory processes: from molecules to man
    Calder, Philip C.
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2017, 45 : 1105 - 1115
  • [8] DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation
    Duvall, Melody G.
    Levy, Bruce D.
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 785 : 144 - 155
  • [9] A REVIEW OF THE USE OF SALIVA COTININE AS A MARKER OF TOBACCO-SMOKE EXPOSURE
    ETZEL, RA
    [J]. PREVENTIVE MEDICINE, 1990, 19 (02) : 190 - 197
  • [10] Methods for Quantification of Exposure to Cigarette Smoking and Environmental Tobacco Smoke: Focus on Developmental Toxicology
    Florescu, Ana
    Ferrence, Roberta
    Einarson, Tom
    Selby, Peter
    Soldin, Offie
    Koren, Gideon
    [J]. THERAPEUTIC DRUG MONITORING, 2009, 31 (01) : 14 - 30