Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study

被引：0

作者：

Liu, Qinwei ^{[1
,3
]}

Liao, Wenjing ^{[2
]}

Yang, Li ^{[1
]}

Cao, Longfei ^{[4
]}

Liu, Ningning ^{[5
,6
]}

Gu, Yongxue ^{[7
]}

Wang, Shaohua ^{[8
,9
]}

Xu, Xiaobin ^{[1
,10
]}

Wang, Huafen ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Peoples R China

[2] Zhejiang Univ, Childrens Hosp, Natl Childrens Reg Med Ctr, Natl Clin Res Ctr Child Hlth,Sch Med,Dept Psychol, Hangzhou 310052, Peoples R China

[3] Zhejiang Univ, Coll Opt Sci & Engn, Hangzhou 310027, Peoples R China

[4] Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Affiliated Hosp, Hangzhou 311121, Peoples R China

[5] Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China

[6] Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Beijing 100191, Peoples R China

[7] Weifang Peoples Hosp, Weifang 261041, Peoples R China

[8] Zhejiang Univ, Affiliated Mental Hlth Ctr, Sch Med, Hangzhou 310000, Peoples R China

[9] Zhejiang Univ, Hangzhou Peoples Hosp 7, Sch Med, Hangzhou 310000, Peoples R China

[10] Zhejiang Herymed Technol Co Ltd, Hangzhou 310058, Peoples R China

来源：

BMC PSYCHIATRY | 2024年 / 24卷 / 01期

关键词：

Subtypes of ADHD; Functional near-infrared spectroscopy; Amplitude of low-frequency fluctuation; Functional connectivity; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT; TASK;

D O I：

10.1186/s12888-024-06350-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with different subtypes of pathogenesis. Insufficient research on the subtypes of ADHD has limited the effectiveness of therapeutic methods.MethodsThis study used resting-state functional near-infrared spectroscopy (fNIRS) to record hemodynamic signals in 34 children with ADHD-combined subtype (ADHD-C), 52 children with ADHD-inattentive subtype (ADHD-I), and 24 healthy controls (HCs). The amplitude of low-frequency fluctuation (ALFF) and the functional connectivity (FC) analysis were conducted for all subjects.ResultsCompared with HCs, the ADHD group exhibited significantly increased ALFF and decreased FC. The ADHD-C group showed significantly higher ALFF in partial brain regions and significantly lower FC between multiple brain regions than participants with ADHD-I. The male group displayed a significant increase in ALFF in some brain regions, while no significant difference was found in FC when compared to the female group.ConclusionsThis study provides evidence to support the subtype classification of ADHD-I and ADHD-C, and the combined analysis of ALFF and FC has the potential to be a promising biomarker for the diagnosis of ADHD.

引用

页数：11