An overview on the interaction between non-coding RNAs and CTLA-4 gene in human diseases

被引:1
作者
Ebrahimi, Amir [1 ]
Barati, Tahereh [1 ]
Mirzaei, Zohreh [1 ]
Fattahi, Fatemeh [1 ]
Derakhshan, Sima Mansoori [1 ]
Khaniani, Mahmoud Shekari [1 ]
机构
[1] Tabriz Univ Med Genet, Fac Med, Dept Med Genet, Tabriz, Iran
关键词
CTLA-4; miRNA; lncRNA; circRNA; Disease; T-CELLS; TUMOR MICROENVIRONMENT; ANTITUMOR IMMUNITY; 1ST-LINE TREATMENT; LUNG-CANCER; PROGNOSIS; ASSOCIATION; MIR-155; IDENTIFICATION; CHECKPOINT;
D O I
10.1007/s12032-024-02552-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cytotoxic T lymphocyte antigen 4 (CTLA-4), in conjunction with PD-1 and CD28, plays a pivotal role in the modulation of T-cell activation. Specifically, CTLA-4 exerts its influence by impeding the generation of IL-2 and the proliferation of T cells. CTLA-4, being a receptor with a high affinity, engages in competitive binding with CD28 for the interaction with primary T-cell activator molecules, specifically CD80 and CD86. The appropriate functioning of T-cell activation is contingent upon maintaining a precise equilibrium between CTLA-4 and CD28. Consequently, any disruption in the expression of CTLA-4 significantly enhances the risk for a range of severe ailments, such as cancer, infectious diseases, allergies, and notably autoimmune diseases. The significance of epigenetic regulation of CTLA-4, particularly through non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), has considerable weight within this particular framework. To date, there have been associations shown between various abnormalities in the expression of ncRNAs that regulate CTLA-4 and clinicopathological characteristics. Nevertheless, it is evident that there is a lack of a comprehensive investigation. Hence, the present work was undertaken to summarize the existing research on the epigenetic control of CTLA-4, with a primary emphasis on elucidating the regulatory procedures, biological processes, and clinical applications in human diseases. The objective of this review is to acquire a thorough comprehension of the relationship between RNA/lncRNA/miRNA/mRNA (CTLA-4) and its role in the progression of diverse human disorders.
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页数:19
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