Nanosized Platform Based on Magnetic Nanoparticles for Photodynamic Therapy in Oncology

被引：0

作者：

Bychkova, A. V. ^{[1
]}

Markova, A. A. ^{[1
]}

Nguyen, M. T. ^{[1
]}

Gradova, M. A. ^{[2
]}

Gorobets, M. G. ^{[1
]}

Motyakin, M. V. ^{[1
]}

Abdullina, M. I. ^{[1
]}

Toroptseva, A. V. ^{[1
]}

Kuzmin, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow, Russia

[2] Russian Acad Sci, Semenov Fed Res Ctr Chem Phys, Moscow, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B | 2024年 / 18卷 / 06期

关键词：

human serum albumin; iron oxide nanoparticles; magnetic nanoparticles; photodynamic therapy; hybrid nanosystems; methylene blue; MCF-7 cell line; IRON-OXIDE NANOPARTICLES; HUMAN SERUM-ALBUMIN; METHYLENE-BLUE; CYANINE DYES; IN-VIVO; PHOTOSENSITIZER; DELIVERY; PROTEIN; PORPHYRINS; CORONA;

D O I：

10.1134/S199079312470129X

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Hybrid nanosystems based on iron oxide nanoparticles (IONPs) and human serum albumin (HSA) were synthesized. The size and composition of HSA@IONP nanosystems were characterized using UV/visible spectrophotometry (particularly, using the Bradford protein assay), dynamic light scattering (DLS), and electron magnetic resonance. The dark and photoinduced cytotoxicity of these systems were studied using methylene blue (MB) as a model photosensitizer (PS). The analysis of the survival of cultured tumor cells of the human breast adenocarcinoma line MCF-7 showed an increase in photoinduced cytotoxicity upon excitation of the PS accumulated by cells due to delivery via the nanosystems, compared to the free PS in equivalent concentrations. HSA@IONPs are discussed as a promising platform for the targeted delivery of a PS to tumor cells.

引用

页码：1619 / 1625

页数：7

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