Association between the composite dietary antioxidant index and erectile dysfunction in US men: a cross-sectional study

被引:0
|
作者
Jin, Xuefeng [1 ]
Sun, Li [2 ]
Li, Hangxu [3 ]
Liu, Yan [4 ]
机构
[1] Jinzhou Med Univ, Jinzhou 121001, Liaoning, Peoples R China
[2] Nantong Univ, Nantong 226019, Jiangsu, Peoples R China
[3] Jinzhou Med Univ, Affiliated Hosp 3, Dept Urol, Jinzhou 121001, Liaoning, Peoples R China
[4] Jinzhou Med Univ, Affiliated Hosp 1, Dept Urol, Jinzhou 121001, Liaoning, Peoples R China
关键词
NHANES; Composite dietary antioxidant index (CDAI); Erectile dysfunction (ED); Propensity score matching (PSM); Exogenous antioxidant intake; OXIDATIVE STRESS; CANCER; RISK; ENDOTHELIUM; GENE;
D O I
10.1186/s41043-024-00653-w
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background Erectile dysfunction (ED) is a common issue among adult males. The Composite Dietary Antioxidant Index (CDAI) reflects anti-inflammatory levels and has been linked to various diseases, but its relationship with ED is unclear. Materials and methods This cross-sectional study utilised comprehensive data on clinical factors from the 2001-2004 National Health and Nutrition Examination Survey (NHANES). To investigate the link between variables and ED, we used multivariate regression analysis, univariate analysis, and subgroup analysis. The linear relationship between CDAI and ED was investigated by dose-response curve analysis. For sensitivity analysis, propensity score matching (PSM) was utilised to exclude the influence of potential confounders. Finally, we investigated the association between CDAI and ED using threshold effects analysis. Results We included in our research a total of 2896 persons with data on CDAI from NHANES 2001-2004. Among these, 2,098 participants were thought to be free of ED, whereas 798 participants had ED. We found that compared to the ED group, men in the non-ED group had higher levels of CDAI (p < 0.0001 before PSM and p = 0.0145 after PSM). Additionally, after adjusting for covariates, it was found that an elevated CDAI was associated with a reduced incidence of ED [OR = 0.65(p = 0.001) before PSM and OR = 0.62(p = 0.002) after PSM]. Subgroup analysis indicated stronger associations in high-risk groups, and dose-response curves confirmed a linear negative correlation between CDAI and ED. Conclusions This study revealed a negative linear relationship between CDAI and the incidence of ED. The CDAI can be used as an indicator for assessing ED risk and for ED prevention.
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页数:13
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