The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined

被引：2

作者：

Jiang, Haoran ^{[1
,2
]}

Kittipibul, Veraprapas ^{[2
,3
]}

Mahfoud, Felix ^{[4
,5
,6
]}

Boehm, Michael ^{[7
]}

Sobotka, Paul A. ^{[8
]}

Esler, Murray ^{[9
]}

Wang, Jie ^{[10
,11
]}

Fudim, Marat ^{[2
,3
]}

机构：

[1] Duke Univ, Sch Med, Durham, NC USA

[2] Duke Univ, Dept Med, Med Ctr, Durham, NC USA

[3] Duke Clin Res Inst, Durham, NC USA

[4] Univ Hosp Basel, Univ Heart Ctr, Dept Cardiol, Basel, Switzerland

[5] Univ Hosp Basel, Univ Heart Ctr, Cardiovasc Res Inst Basel CRIB, Basel, Switzerland

[6] MIT, Inst Med Engn & Sci, Cambridge, MA USA

[7] Saarland Univ, Saarland Univ Hosp, Dept Internal Med Cardiol Angiol & Intens Care Med, Homburg, Germany

[8] Ohio State Univ, COLL MED,DEPT CARDIOL, Coll Med, COLUMBUS, OH 43210 USA

[9] Baker IDI Heart & Diabet Inst, Melbourne, Australia

[10] Nanjing Med Univ, Dept Hematol, Affiliated Hosp 1, Nanjing, Peoples R China

[11] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Cardiol, Columbia, NY USA

来源：

HEART FAILURE REVIEWS | 2025年 / 30卷 / 02期

关键词：

Hypertension; Renal denervation; Renal nerves; Heart failure; TREATMENT-RESISTANT HYPERTENSION; SYMPATHETIC-NERVOUS-SYSTEM; BLOOD-PRESSURE; PARASYMPATHETIC INNERVATION; NEURAL-CONTROL; AFFERENT; CATHETER; NERVES; ARTERY; FIBERS;

D O I：

10.1007/s10741-024-10463-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interruption of sympathetic nerves connecting the kidney and the sympathetic nervous system can reduce blood pressure. Here, we present a review on how renal denervation can help hypertension patients, specifically focusing on our novel understanding of renal nerve anatomy, denervation technique, and subsequent clinical trials, and how it may be used to treat other cardiovascular diseases like heart failure.

引用

页码：293 / 314

页数：22

共 88 条

[41] The SPYRAL HTN Global Clinical Trial Program: Rationale and design for studies of renal denervation in the absence (SPYRAL HTN OFF-MED) and presence (SPYRAL HTN ON-MED) of antihypertensive medications [J].

Kandzari, David E. ;

Kario, Kazuomi ;

Mahfoud, Felix ;

Cohen, Sidney A. ;

Pilcher, Garrett ;

Pocock, Stuart ;

Townsend, Raymond ;

Weber, Michael A. ;

Boehm, Michael .

AMERICAN HEART JOURNAL, 2016, 171 (01) :82-91

[42] Predictors of blood pressure response in the SYMPLICITY HTN-3 trial [J].

Kandzari, David E. ;

Bhatt, Deepak L. ;

Brar, Sandeep ;

Devireddy, Chandan M. ;

Esler, Murray ;

Fahy, Martin ;

Flack, John M. ;

Katzen, Barry T. ;

Lea, Janice ;

Lee, David P. ;

Leon, Martin B. ;

Ma, Adrian ;

Massaro, Joseph ;

Mauri, Laura ;

Oparil, Suzanne ;

O'Neill, William W. ;

Patel, Manesh R. ;

Rocha-Singh, Krishna ;

Sobotka, Paul A. ;

Svetkey, Laura ;

Townsend, Raymond R. ;

Bakris, George L. .

EUROPEAN HEART JOURNAL, 2015, 36 (04) :219-227

[43] Catheter-based ultrasound renal denervation in patients with resistant hypertension: the randomized, controlled REQUIRE trial [J].

Kario, Kazuomi ;

Yokoi, Yoshiaki ;

Okamura, Keisuke ;

Fujihara, Masahiko ;

Ogoyama, Yukako ;

Yamamoto, Eiichiro ;

Urata, Hidenori ;

Cho, Jin-Man ;

Kim, Chong-Jin ;

Choi, Seung-Hyuk ;

Shinohara, Keisuke ;

Mukai, Yasushi ;

Ikemoto, Tomokazu ;

Nakamura, Masato ;

Seki, Shuichi ;

Matoba, Satoaki ;

Shibata, Yoshisato ;

Sugawara, Shigeo ;

Yumoto, Kazuhiko ;

Tamura, Kouichi ;

Yoshihara, Fumiki ;

Nakamura, Satoko ;

Kang, Woong Chol ;

Shibasaki, Taro ;

Dote, Keigo ;

Yokoi, Hiroyoshi ;

Matsuo, Akiko ;

Fujita, Hiroshi ;

Takahashi, Toshiyuki ;

Kang, Hyun-Jae ;

Sakata, Yasushi ;

Horie, Kazunori ;

Inoue, Naoto ;

Sasaki, Ken-ichiro ;

Ueno, Takafumi ;

Tomita, Hirofumi ;

Morino, Yoshihiro ;

Nojima, Yuhei ;

Kim, Chan Joon ;

Matsumoto, Tomoaki ;

Kai, Hisashi ;

Nanto, Shinsuke .

HYPERTENSION RESEARCH, 2022, 45 (02) :221-231

[44] Trends in Healthcare Expenditures Among US Adults With Hypertension: National Estimates, 2003-2014 [J].

Kirkland, Elizabeth B. ;

Heincelman, Marc ;

Bishu, Kinfe G. ;

Schumann, Samuel O. ;

Schreiner, Andrew ;

Axon, R. Neal ;

Mauldin, Patrick D. ;

Moran, William P. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (11)

[45]

KLINE RL, 1978, CAN J PHYSIOL PHARM, V56, P818, DOI 10.1139/y78-128

[46]

KNUEPFER MM, 1987, BRAIN RES, V435, P167

[47] Nitric oxide modulates renal sensory nerve fibers by mechanisms related to substance P receptor activation [J].

Kopp, UC ;

Cicha, MZ ;

Smith, LA ;

Hökfelt, T .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 281 (01) :R279-R290

[48] Role of renal sensory nerves in physiological and pathophysiological conditions [J].

Kopp, Ulla C. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2015, 308 (02) :R79-R95

[49]

Kottke F. J., 1945, AMER JOUR PHYSIOL, V145, P38

[50] Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study [J].

Krum, Henry ;

Schlaich, Markus P. ;

Sobotka, Paul A. ;

Boehm, Michael ;

Mahfoud, Felix ;

Rocha-Singh, Krishna ;

Katholi, Richard ;

Esler, Murray D. .

LANCET, 2014, 383 (9917) :622-629

← 1 2 3 4 5 6 7 8 9 →