The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined

被引：2

作者：

Jiang, Haoran ^{[1
,2
]}

Kittipibul, Veraprapas ^{[2
,3
]}

Mahfoud, Felix ^{[4
,5
,6
]}

Boehm, Michael ^{[7
]}

Sobotka, Paul A. ^{[8
]}

Esler, Murray ^{[9
]}

Wang, Jie ^{[10
,11
]}

Fudim, Marat ^{[2
,3
]}

机构：

[1] Duke Univ, Sch Med, Durham, NC USA

[2] Duke Univ, Dept Med, Med Ctr, Durham, NC USA

[3] Duke Clin Res Inst, Durham, NC USA

[4] Univ Hosp Basel, Univ Heart Ctr, Dept Cardiol, Basel, Switzerland

[5] Univ Hosp Basel, Univ Heart Ctr, Cardiovasc Res Inst Basel CRIB, Basel, Switzerland

[6] MIT, Inst Med Engn & Sci, Cambridge, MA USA

[7] Saarland Univ, Saarland Univ Hosp, Dept Internal Med Cardiol Angiol & Intens Care Med, Homburg, Germany

[8] Ohio State Univ, COLL MED,DEPT CARDIOL, Coll Med, COLUMBUS, OH 43210 USA

[9] Baker IDI Heart & Diabet Inst, Melbourne, Australia

[10] Nanjing Med Univ, Dept Hematol, Affiliated Hosp 1, Nanjing, Peoples R China

[11] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, Div Cardiol, Columbia, NY USA

来源：

HEART FAILURE REVIEWS | 2025年 / 30卷 / 02期

关键词：

Hypertension; Renal denervation; Renal nerves; Heart failure; TREATMENT-RESISTANT HYPERTENSION; SYMPATHETIC-NERVOUS-SYSTEM; BLOOD-PRESSURE; PARASYMPATHETIC INNERVATION; NEURAL-CONTROL; AFFERENT; CATHETER; NERVES; ARTERY; FIBERS;

D O I：

10.1007/s10741-024-10463-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interruption of sympathetic nerves connecting the kidney and the sympathetic nervous system can reduce blood pressure. Here, we present a review on how renal denervation can help hypertension patients, specifically focusing on our novel understanding of renal nerve anatomy, denervation technique, and subsequent clinical trials, and how it may be used to treat other cardiovascular diseases like heart failure.

引用

页码：293 / 314

页数：22

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