Dual-responsive Tumbleweed-inspired Soft Robot Based on Poly(N-isopropylacrylamide) and MoS2 for Targeted Drug Delivery in Stomach

被引：0
|
作者：
Teng, Xiangyu [1 ]
Yu, Shuxuan [1 ]
Qiao, Zezheng [1 ]
Ge, Zhixing [2 ]
Yang, Wenguang [1 ]
机构：
[1] Yantai Univ, Sch Electromech & Automot Engn, Yantai 264005, Peoples R China
[2] Natl Univ Singapore, Dept Biomed Engn, Singapore 999002, Singapore
来源：
JOURNAL OF BIONIC ENGINEERING | 2025年 / 22卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Bioinspiration; Soft robot; Light-activated; Magnetically actuated; Targeted drug delivery;
D O I：
10.1007/s42235-025-00650-7
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N-isopropylacrylamide) and MoS2. Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS2, the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.
引用
收藏
页码：562 / 573
页数：12
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