Burden of Respiratory Syncytial Virus Disease in Adults with Asthma and Chronic Obstructive Pulmonary Disease: A Systematic Literature Review

被引:0
|
作者
Penders, Yolanda [1 ]
Brusselle, Guy [2 ]
Falsey, Ann R. [3 ]
Rohde, Gernot [4 ]
Betancur, Estefania [5 ]
Guardado, Maria Elena [5 ]
Agudelo, Juan Luis Ramirez [5 ]
Saeedi, Pouya [1 ]
Harrington, Lauriane [1 ]
Michaud, Jean-Philippe [1 ]
机构
[1] GSK, Av Fleming 20, B-1300 Wavre, Belgium
[2] Ghent Univ Hosp, Dept Resp Med, B-9000 Ghent, Belgium
[3] UNIV ROCHESTER, Sch Med, ROCHESTER, NY 14642 USA
[4] Goethe Univ Frankfurt, Univ Hosp, Dept Resp Med, Med Clin 1, D-60590 Frankfurt, Germany
[5] P95, B-3000 Leuven, Belgium
关键词
Adults; Asthma; Chronic obstructive pulmonary disease; Complications; Hospitalization; Respiratory viral infection; RISK-FACTORS; CLINICAL CHARACTERISTICS; OLDER-ADULTS; INFECTION; EXACERBATIONS; PREVALENCE; HOSPITALIZATION; PNEUMONIA; RSV;
D O I
10.1007/s11882-025-01194-w
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of ReviewAccumulating data indicate that asthma and chronic obstructive pulmonary disease (COPD) increase the risk of severe respiratory syncytial virus (RSV) infection. This systematic literature review assessed the burden of RSV disease among adults >= 18 years with asthma or COPD.Recent FindingsData on the prevalence of asthma or COPD among RSV-infected adults, RSV-related hospitalizations, complications, and mortality were collected from studies published between January 1, 2000 and November 28, 2023 in PubMed, Embase, and grey literature. All extracted data were analyzed descriptively. Pooled estimates of asthma or COPD prevalence among RSV-infected adults were calculated from generalized linear mixed effects model meta-analyses. Forty studies were included. The prevalence of asthma and COPD among RSV-infected adults was high, especially in inpatient settings with pooled estimates (95% confidence interval) of 19.3% (15.0-24.6) for asthma and 30.8% (26.1-36.0) for COPD. Adults with asthma or COPD were more likely to be hospitalized following RSV infection than those without these conditions. The incidence rate ratios of hospitalization were 2.0-3.6 (crude) and 6.7-8.2 (adjusted) for asthma and 3.2-13.4 (crude) and 9.6-9.7 (adjusted) for COPD. The most frequently reported RSV-related complications were exacerbation of asthma (up to 64.9%) and COPD (up to >= 83.0%). In-hospital case fatality rates were 2.6-4.3% (asthma) and 2.8-17.8% (COPD).SummaryThese comprehensive data showing a high RSV disease burden in adults with asthma or COPD can be used to inform policy decisions around RSV vaccines and improve preventive care in this high-risk population.
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页数:16
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