Research progress on the signaling pathway mechanism of terpenoids against breast cancer

被引:0
作者
Tu, Sheng-nan [1 ]
Hu, Fen [2 ]
Zhang, Juan [3 ]
Cai, Haifeng [3 ]
Yang, Junquan [1 ]
机构
[1] North China Univ Sci & Technol, Sch Clin Med, Tangshan 063210, Peoples R China
[2] North China Univ Sci & Technol, Coll Life Sci, Tangshan 063210, Peoples R China
[3] Tangshan Peoples Hosp, Dept Mammary Gland 2, Tangshan 063000, Peoples R China
关键词
Breast cancer; Terpenoids; Signal passage; Review; CELL-CYCLE ARREST; OXIDATIVE STRESS; APOPTOSIS; LYCOPENE; GROWTH; INVASIVENESS; COMBINATION; INVOLVEMENT; METASTASIS; INHIBITION;
D O I
10.1007/s12672-025-01881-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is the most common malignant tumor in women worldwide. Current treatments include chemotherapy, hormone therapy, radiotherapy and surgery. Terpenoids have great anti-cancer potential due to their anti-inflammatory, antioxidant, anti-tumor, antiviral and other biological activities. They have become the central drug for the prevention and treatment of breast cancer. However, their low bioavailability and stability are urgent issues that need to be addressed. This article aims to sort out the mechanism of action of terpenoids in the treatment of breast cancer. By reviewing different signal transduction pathways, it is hoped that new ideas for the joint action of multiple pathways and multiple targets will be provided, and a theoretical basis will be provided for improving basic research and clinical treatment of breast cancer.
引用
收藏
页数:18
相关论文
共 84 条
  • [1] Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells
    Alsamri, Halima
    Alneyadi, Aysha
    Muhammad, Khalid
    Ayoub, Mohammed Akli
    Eid, Ali
    Iratni, Rabah
    [J]. FRONTIERS IN ONCOLOGY, 2022, 12
  • [2] Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression
    Asl, Elmira Roshani
    Amini, Mohammad
    Najafi, Souzan
    Mansoori, Behzad
    Mokhtarzadeh, Ahad
    Mohammadi, Ali
    Lotfinejad, Parisa
    Bagheri, Mehdi
    Shirjang, Solmaz
    Lotfi, Ziba
    Rasmi, Yousef
    Baradaran, Behzad
    [J]. LIFE SCIENCES, 2021, 278
  • [3] Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells
    Assar, Emelia A.
    Vidalle, Magdalena Castellano
    Chopra, Mridula
    Hafizi, Sassan
    [J]. TUMOR BIOLOGY, 2016, 37 (07) : 9375 - 9385
  • [4] Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research
    Ateba, Sylvin Benjamin
    Mvondo, Marie Alfrede
    Ngeu, Sadrine Tchoukouegno
    Tchoumtchoual', Job
    Awounfackl, Charline Florence
    Njamen, Dieudonne
    Krenn, Liselotte
    [J]. CURRENT MEDICINAL CHEMISTRY, 2018, 25 (27) : 3162 - 3213
  • [5] Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    Bishayee, Anupam
    Ahmed, Shamima
    Brankov, Nikoleta
    Perloff, Marjorie
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2011, 16 : 980 - 996
  • [6] Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice
    Changizi, Zahra
    Moslehi, Azam
    Rohani, Ali Haeri
    Eidi, Akram
    [J]. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021, 35 (02)
  • [7] Anti-Cancer Effect of Sesquiterpene and Triterpenoids from Agarwood of Aquilaria sinensis
    Chen, Lili
    Liu, Yunyun
    Li, Yifei
    Yin, Wu
    Cheng, Yongxian
    [J]. MOLECULES, 2022, 27 (16):
  • [8] Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics
    Chou, Yi-Ju
    Lin, Ching-Cheng
    Hsu, Ya-Chi
    Syu, Jia-Ling
    Tseng, Ling-Ming
    Chiu, Jen-Hwey
    Lo, Jeng-Fan
    Lin, Chao-Hsiung
    Fu, Shu-Ling
    [J]. BIOCHEMICAL PHARMACOLOGY, 2022, 206
  • [9] Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2 to regulate immune microenvironment and apoptosis
    Dong, Fangming
    Qu, Linlin
    Duan, Zhiguang
    He, Ying
    Ma, Xiaoxuan
    Fan, Daidi
    [J]. BIOORGANIC CHEMISTRY, 2023, 135
  • [10] Antitumor and anti-angiogenic effects of artemisinin on breast tumor xenografts in nude mice
    Dong, Jing
    Chen, Yuelei
    Yang, Wenhui
    Zhang, Xi
    Li, Lin
    [J]. RESEARCH IN VETERINARY SCIENCE, 2020, 129 : 66 - 69