Hallmarks of primary headache: part 1-migraine

被引：16

作者：

Raggi, Alberto ^{[1
]}

Leonardi, Matilde ^{[1
]}

Arruda, Marco ^{[2
]}

Caponnetto, Valeria ^{[3
]}

Castaldo, Matteo ^{[4
,5
]}

Coppola, Gianluca ^{[6
]}

Della Pietra, Adriana ^{[7
]}

Fan, Xiangning ^{[8
]}

Garcia-Azorin, David ^{[9
,10
]}

Gazerani, Parisa ^{[4
,11
]}

Grangeon, Lou ^{[12
]}

Grazzi, Licia ^{[13
]}

Hsiao, Fu-Jung ^{[14
]}

Ihara, Keiko ^{[15
,16
]}

Labastida-Ramirez, Alejandro ^{[17
]}

Lange, Kristin Sophie ^{[18
,19
,20
]}

Lisicki, Marco ^{[21
]}

Marcassoli, Alessia ^{[1
]}

Montisano, Danilo Antonio ^{[13
]}

Onan, Dilara ^{[22
]}

Onofri, Agnese ^{[23
]}

Pellesi, Lanfranco ^{[24
]}

Peres, Mario ^{[25
,26
,27
]}

Petrusic, Igor ^{[28
]}

Raffaelli, Bianca ^{[18
,19
,20
]}

Rubio-Beltran, Eloisa ^{[29
]}

Straube, Andreas ^{[30
]}

Straube, Sebastian ^{[8
,31
]}

Takizawa, Tsubasa ^{[15
]}

Tana, Claudio ^{[32
]}

Tinelli, Michela ^{[33
]}

Valeriani, Massimiliano ^{[34
,35
]}

Vigneri, Simone ^{[36
]}

Vuralli, Doga ^{[37
]}

Waliszewska-Prosol, Marta ^{[38
]}

Wang, Wei ^{[39
,40
]}

Wang, Yonggang ^{[41
]}

Wells-Gatnik, William ^{[42
]}

Wijeratne, Tissa ^{[43
,44
]}

Martelletti, Paolo ^{[42
]}

机构：

[1] Fdn IRCCS Ist Neurol Carlo Besta, Publ Hlth & Disabil Unit, Via Celoria 11, I-20133 Milan, Italy

[2] Glia Inst, Ribeirao Preto, Brazil

[3] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy

[4] Aalborg Univ, Fac Med, Ctr Sensory Motor Interact SMI, Dept Hlth Sci & Technol,CNAP, Gistrup, Denmark

[5] Univ Parma, Dept Med & Surg, Clin Psychophysiol & Clin Neuropsychol Labs, Parma, Italy

[6] Sapienza Univ Rome Polo Pontino ICOT, Dept Med Surg Sci & Biotechnol, Latina, Italy

[7] Univ Iowa, Carver Coll Med, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA

[8] Univ Alberta, Dept Med, Edmonton, AB, Canada

[9] Univ Valladolid, Fac Med, Dept Med Toxicol & Dermatol, Valladolid, Spain

[10] Hosp Univ Rio Hortega, Dept Neurol, Valladolid, Spain

[11] Oslo Metropolitan Univ, Fac Hlth Sci, Dept Life Sci & Hlth, Oslo, Norway

[12] CHU Rouen, Dept Neurol, Rouen, France

[13] Fdn IRCCS Ist Neurol Carlo Besta, Headache Ctr, Neuroalgol Unit, Milan, Italy

[14] Natl Yang Ming Chiao Tung Univ, Brain Res Ctr, Taipei, Taiwan

[15] Keio Univ, Sch Med, Dept Neurol, Tokyo, Japan

[16] Japanese Red Cross Ashikaga Hosp, Tochigi, Japan

[17] Univ Manchester, Fac Biol Med & Hlth, Div Neurosci, Manchester, England

[18] Humboldt Univ, Dept Neurol, Charite Univ Med Berlin, D-10117 Berlin, Germany

[19] Humboldt Univ, Berlin, Germany

[20] Charite Univ Med Berlin, Freie Univ Berlin, Berlin Inst Hlth, D-10117 Berlin, Germany

[21] Univ Nacl Cordoba, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Med Mercedes & Martin Ferreyra INIMEC, Cordoba, Argentina

[22] Yozgat Bozok Univ, Fac Heath Sci, Dept Physiotherapy & Rehabil, Yozgat, Turkiye

[23] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy

[24] Univ Southern Denmark, Dept Publ Hlth, Clin Pharmacol Pharm & Environm Med, Odense, Denmark

[25] Hosp Israelita Albert Einstein, Sao Paulo, Brazil

[26] Inst Psiquiatria, BR-OS430010 Sao Paulo, Brazil

[27] Hosp Clin Fac Med USP, Sao Paulo, Brazil

[28] Univ Belgrade, Fac Phys Chem, Lab Adv Anal Neuroimages, Belgrade, Serbia

[29] Kings Coll London, Inst Psychiat Psychol & Neurosci, Headache Grp, Wolfson SPaRC, London, England

[30] LMU Univ Hosp, Dept Neurol, Munich, Germany

[31] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada

[32] SS Annunziata Hosp Chieti, Ctr Excellence, Headache & Geriatr Clin, Chieti, Italy

[33] London Sch Econ & Polit Sci, Care Policy & Evaluat Ctr CPEC, London, England

[34] Univ Tor Vergata, Syst Med, Rome, Italy

[35] IRCSS Osped Pediatr Bambino Gesu, Dev Neurol Unit, Rome, Italy

[36] Santa Maria Maddalena Hosp, Neurol & Neurophysiol Serv, Pain Med Unit, Occhiobello, Italy

[37] Gazi Univ, Neurosci & Neurotechnol Ctr Excellence NOROM, Dept Neurol & Algol, Dept Neurol & Algol,Fac Med, Ankara, Turkiye

[38] Wroclaw Med Univ, Div Pathomorphol, PL-50556 Wroclaw, Poland

[39] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Neurol, Sch Med,Headache Ctr, Hangzhou, Peoples R China

[40] Capital Med Univ, Beijing Tiantan Hosp, Headache Ctr, Dept Neurol, Beijing, Peoples R China

[41] Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China

[42] Unitelma Sapienza Univ Rome, Rome, Italy

[43] Sunshine Hosp, Dept Neurol, St Albans, Vic, Australia

[44] Pascoe Vale South, Australian Inst Migraine, 522 Bell St, Melbourne, Vic 3044, Australia

来源：

JOURNAL OF HEADACHE AND PAIN | 2024年 / 25卷 / 01期

关键词：

Migraine; Aura; Medication overuse headache; Calcitonin gene-related peptide; CGRP; Gepants; Triptans; Ditans; Productivity loss; CYCLASE-ACTIVATING POLYPEPTIDE; TRANSCRANIAL MAGNETIC STIMULATION; FAMILIAL HEMIPLEGIC MIGRAINE; GENE-RELATED PEPTIDE; QUALITY-OF-LIFE; CORTICAL SPREADING DEPRESSION; COGNITIVE-BEHAVIORAL THERAPY; TENSION-TYPE HEADACHE; CEREBRAL BLOOD-FLOW; ADENYLATE-CYCLASE;

D O I：

10.1186/s10194-024-01889-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and aimMigraine is a common disabling conditions which, globally, affects 15.2% of the population. It is the second cause of health loss in terms of years lived with disability, the first among women. Despite being so common, it is poorly recognised and too often undertreated. Specialty centres and neurologists with specific expertise on headache disorders have the knowledge to provide specific care: however, those who do not regularly treat patients with migraine will benefit from a synopsis on the most relevant and updated information about this condition. This paper presents a comprehensive view on the hallmarks of migraine, from genetics and diagnostic markers, up to treatments and societal impact, and reports the elements that identify migraine specific features.Main resultsThe most relevant hallmark of migraine is that it has common and individual features together. Besides the known clinical manifestations, migraine presentation is heterogeneous with regard to frequency of attacks, presence of aura, response to therapy, associated comorbidities or other symptoms, which likely reflect migraine heterogeneous genetic and molecular basis. The amount of therapies for acute and for prophylactic treatment is really wide, and one of the difficulties is with finding the best treatment for the single patient. In addition to this, patients carry out different daily life activities, and might show lifestyle habits which are not entirely adequate to manage migraine day by day. Education will be more and more important as a strategy of brain health promotion, because this will enable reducing the amount of subjects needing specialty care, thus leaving it to those who require it in reason of refractory condition or presence of comorbidities.ConclusionsRecognizing the hallmarks of migraine and the features of single patients enables prescribing specific pharmacological and non-pharmacological treatments. Medical research on headaches today particularly suffers from the syndrome of single-disease approach, but it is important to have a cross-sectional and joint vision with other close specialties, in order to treat our patients with a comprehensive approach that a heterogeneous condition like migraine requires.

引用

页数：47

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