The impact of preoperative immunonutritional status on prognosis in ovarian cancer: a multicenter real-world study

被引：1

作者：

Liu, Xingyu ^{[1
,2
]}

Li, Ming ^{[3
]}

Zhao, Yingjun ^{[3
]}

Jiao, Xiaofei ^{[1
,2
]}

Yu, Yang ^{[1
,2
]}

Li, Ruyuan ^{[4
]}

Zeng, Shaoqing ^{[1
,2
]}

Chi, Jianhua ^{[1
,2
]}

Ma, Guanchen ^{[1
,2
]}

Huo, Yabing ^{[1
,2
]}

Peng, Zikun ^{[1
,2
]}

Liu, Jiahao ^{[1
,2
]}

Zhou, Qi ^{[5
,6
,7
]}

Zou, Dongling ^{[4
,5
,6
]}

Wang, Li ^{[8
,9
]}

Li, Qingshui ^{[10
]}

Wang, Jing ^{[11
,12
,13
,14
]}

Yao, Shuzhong ^{[15
]}

Chen, Youguo ^{[16
]}

Ma, Ding ^{[1
,2
]}

Hu, Ting ^{[1
,2
]}

Gao, Qinglei ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gynecol Oncol, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll,Key Lab,Minist Educ, Natl Clin Res Ctr Obstet & Gynecol,Canc Biol Res C, 1095 Jiefang Ave, Wuhan 430000, Peoples R China

[3] Henan Prov Peoples Hosp, Dept Gynaecol & Obstet, Zhengzhou, Henan, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Beijing, Peoples R China

[5] Chongqing Univ, Canc Hosp, Dept Gynecol Oncol, Chongqing, Peoples R China

[6] Chongqing Univ, Chongqing Key Lab Translat Res Canc Metastasis & I, Canc Hosp, Chongqing, Peoples R China

[7] Chongqing Univ, Canc Hosp, Key Lab Biorheol Sci &Technol, Minist Educ, Chongqing, Peoples R China

[8] Zhengzhou Univ, Dept Canc Biol Immunotherapy, Affiliated Canc Hosp, Zhengzhou, Henan, Peoples R China

[9] Henan Canc Hosp, Zhengzhou, Henan, Peoples R China

[10] Shandong Canc Hosp & Inst, Dept Gynecol Oncol, Jinan, Shandong, Peoples R China

[11] Cent South Univ, Hunan Canc Hosp, Hunan Clin Res Ctr Gynecol Canc, Changsha, Hunan, Peoples R China

[12] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China

[13] Cent South Univ, Hunan Canc Hosp, Dept Gynecol Canc, Changsha, Hunan, Peoples R China

[14] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China

[15] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China

[16] Soochow Univ, Dept Rheumatol, Affiliated Hosp 1, Suzhou, Jiangsu Provinc, Peoples R China

来源：

JOURNAL OF OVARIAN RESEARCH | 2025年 / 18卷 / 01期

关键词：

Ovarian cancer; Preoperative immunonutritional status; Prognostic nutritional index; Systemic immune-inflammation index; Progression-free survival; Overall survival; MALNUTRITION; INFLAMMATION; INDEX; COUNT; RATIO; RISK;

D O I：

10.1186/s13048-025-01607-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundTo investigate the effect of preoperative immunonutritional status on prognosis in epithelial ovarian cancer patients.MethodsA multicenter real-world study included 922 patients with histologically confirmed epithelial ovarian cancer who received comprehensive staged surgery or debulking surgery at seven tertiary hospitals in China between 2012 and 2023. Prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were used to assess the immunonutritional status for their superior predictive power to indicate the nutritional status and the inflammatory immunity. Cox regression analyses were employed to identify variables associated with progression-free survival (PFS) and overall survival (OS).ResultsIn the early-stage cohort of 224 epithelial ovarian cancer patients, the optimal cut-off value for PNI was 47.47 for both PFS and OS, while the optimal cut-off value for SII values were 551.37 for PFS and 771.78 for OS. In the late-stage group of 698 patients, the optimal PNI thresholds were 47.76 for PFS and 46.00 for OS, with SII values of 720.96 for PFS and 1686.11 for OS. In multivariate analysis of early-stage patients, high PNI was an independent protective factor for PFS (hazard ratio (HR), 0.39 (95% confidence interval (CI) 0.20-0.76), P = 0.006) and OS (HR, 0.44 (95% CI 0.20-0.97), P = 0.042), respectively. High SII was significantly associated with PFS (HR, 2.43 (95% CI 1.23-4.81), P = 0.011) and marginally unfavorable for OS (HR, 2.05 (95% CI 0.96-4.39), P = 0.064). In advanced population, PNI (HR, 0.77 (95% CI 0.60-0.99), P = 0.043) and SII (HR, 1.34 (95% CI 1.01-1.78), P = 0.041) were independent prognostic factors for OS but had no impact on PFS (P = 0.185, P = 0.188, respectively).ConclusionPoor preoperative immunonutritional status has a deleterious effect on the prognosis of patients with ovarian cancer. Intervention in patients suffering from suboptimal preoperative immunonutritional status may facilitate improved survival outcomes.

引用

页数：11

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