Anti-Inflammatory Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones

被引：0
|
作者：
Gein, O. N. [1 ]
Mazunina, I. M. [1 ]
Gein, V. S. [2 ]
Rubtsova, D. D. [1 ]
Gein, V. L. [1 ]
机构：
[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia
[2] Perm State Natl Res Univ, 15 Bukireva St, Perm 614068, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2024年 / 58卷 / 08期
关键词：
anti-inflammatory activity; analgesic activity; pyrrolin-2-ones; 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones; phagocytosis; PYRROLIDINE-2,3-DIONES; INFLAMMATION;
D O I：
10.1007/s11094-024-03268-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The anti-inflammatory activity of new 3-pyrrolin-2-one derivatives, namely, 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones, was studied. The studied 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyalkyl-3-pyrrolin-2-ones exhibited an anti-inflammatory effect, inhibiting swelling of rat paws in an acute exudative inflammation model caused by subplantar injection of carrageenan solution (1%) and did not change the absorption activity of peripheral blood leukocytes. The studied compounds reduced the number of abdominal muscle contractions in mice in a peritovisceral pain model caused by intraperitoneal injection of acetic-acid solution (0.75%).
引用
收藏
页码：1263 / 1266
页数：4
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