Synthesis and Study of Luminescent, Anti-Mao, and Antioxidant Properties of (2E)-3-Aryl-1-(4-alkoxyphenyl)prop-2-ene-1-ones and Their Pyrazoline Derivatives

被引：0

作者：

Hakobyan, N. Z. ^{[1
]}

Isakhanyan, A. U. ^{[1
]}

Grigoryan, G. S. ^{[2
]}

Mkhitaryan, R. P. ^{[2
]}

Sargsyan, H. R. ^{[2
]}

Grigoryan, A. S.

Pahutyan, N. H. ^{[1
]}

Pogosyan, A. E. ^{[1
]}

Arajyan, G. m ^{[1
]}

Gasparyan, H. V. ^{[1
]}

Muradyan, R. Y. ^{[1
]}

Panosyan, H. A. ^{[1
]}

Israelyan, S. G. ^{[1
]}

Harutyunyan, A. A. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia

[2] Yerevan State Univ, Yerevan 0025, Armenia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2024年 / 94卷 / 11期

关键词：

aromatic aldehydes; 1,3-diaryl-2-propene-1-ones; pyrazolines; cyclization; luminescence; antimonoamine oxidase activity; lipid peroxidation; CHALCONE;

D O I：

10.1134/S1070363224110057

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution, (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-ene-1-ones were obtained. Cyclization of these latter with phenylhydrazine in an acidic medium leads to the corresponding 5-aryl-3-(4-alkoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazoles. The luminescent, antimonoamine oxidase, and antioxidant properties of the compounds obtained were studied.

引用

页码：2847 / 2858

页数：12

共 24 条

[1] Standards for photoluminescence quantum yield measurements in solution (IUPAC Technical Report)
Brouwer, Albert M.
[J]. PURE AND APPLIED CHEMISTRY, 2011, 83 (12) : 2213 - 2228
[2] Chebanov V.A, 2008, Azaheterocycles Based on,-Unsaturated Carbonyls, DOI [10.1007/978-3-540-68367-4, DOI 10.1007/978-3-540-68367-4]
[3] Chesnokova N.P., 2009, Fund. Issled, V5, P122
[4] Chalcones: A Valid Scaffold for Monoamine Oxidases Inhibitors
Chimenti, Franco
Fioravanti, Rossella
Bolasco, Adriana
Chimenti, Paola
Secci, Daniela
Rossi, Francesca
Yanez, Matilde
Orallo, Francisco
Ortuso, Francesco
Alcaro, Stefano
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (09) : 2818 - 2824
[5] Gorkin V.Z., 1981, Methods based on the Measurement of Released Ammonia, P34
[6] Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
Guglielmi, Paolo
Carradori, Simone
Poli, Giulio
Secci, Daniela
Cirilli, Roberto
Rotondi, Giulia
Chimenti, Paola
Petzer, Anel
Petzer, Jacobus P.
[J]. MOLECULES, 2019, 24 (03)
[7] Push-Pull Systems Based on 2,4,6-Triarylpyrimidines. 2,4-Diaryl-6-and 2-Aryl-4,6-bis{4-[(E)-2-arylvinyl]phenyl}pyrimidines
Harutyunyan, A. A.
Safaryan, M. S.
Dilanyan, S. V.
Panosyan, H. A.
Danagulyan, G. G.
[J]. RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 59 (02) : 243 - 251
[8] Isakhanyan A.U., 2024, Zh. Obshch. Khim, V94, P80, DOI [10.31857/S0044460X24010065, DOI 10.31857/S0044460X24010065]
[9] Ko G. Tan O.U Uar G Yildirim E Erol K and Palaska E., 2014, Drug Res (Stuttg), V64, P591, DOI [10.1055/s-0033-1363997, DOI 10.1055/S-0033-1363997]
[10] Kohler EP, 1922, ORG SYNTH, V2, P1

← 1 2 3 →