Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations

被引：0

作者：

Ferraretti, Giulia ^{[1
,2
]}

Rill, Aina ^{[1
,2
,15
]}

Abondio, Paolo ^{[3
,16
]}

Smith, Kyra ^{[1
,2
]}

Ojeda-Granados, Claudia ^{[1
,2
,17
]}

De Fanti, Sara ^{[4
]}

Alberti, Marta ^{[1
,2
]}

Izzi, Massimo ^{[5
]}

Sherpa, Phurba T. ^{[6
]}

Cocco, Paolo ^{[7
]}

Tiriticco, Massimiliano ^{[7
]}

Di Marcello, Marco ^{[7
]}

Dezi, Agnese ^{[8
]}

Gnecchi-Ruscone, Guido Alberto ^{[9
,18
,19
]}

Natali, Luca ^{[7
,10
]}

Corcelli, Angela ^{[11
]}

Marinelli, Giorgio ^{[7
]}

Garagnani, Paolo ^{[12
,13
]}

Peluzzi, Davide ^{[7
]}

Luiselli, Donata ^{[3
]}

Pettener, Davide ^{[1
,2
]}

Sarno, Stefania ^{[1
,2
]}

Sazzini, Marco ^{[1
,2
,14
]}

机构：

[1] Univ Bologna, Lab Mol Anthropol, Bologna, Italy

[2] Univ Bologna, Ctr Genome Biol, Dept Biol Geol & Environm Sci, Bologna, Italy

[3] Univ Bologna, Dept Cultural Heritage, Ravenna Campus, Ravenna, Italy

[4] IRCCS Ist Sci Neurolog Bologna, Bologna, Italy

[5] Univ Bologna, Dept Med & Surg Sci, Complex Operat Unit Endocrinol & Diabet Care, Bologna, Italy

[6] Mt Everest Summiters Club, Dolakha, Nepal

[7] Explora Nunaat Int, Teramo, Italy

[8] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Bari, Italy

[9] Max Planck Inst Evolutionary Anthropol, Dept Archaeogenet, Leipzig, Germany

[10] Italian Inst Human Paleontol, Rome, Italy

[11] Univ Bari Aldo Moro, Dept Translat Biomed & Neurosci, Bari, Italy

[12] IRCCS Azienda Ospedaliero Univ Bologna, Bologna, Italy

[13] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy

[14] Univ Bologna, Interdept Ctr Alma Mater Res Inst Global Changes &, Bologna, Italy

[15] Univ Barcelona, Josep Carreras Leukaemia Res Inst, PhD Programme Biomed, Barcelona, Spain

[16] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

[17] Univ Catania, Dept Med & Surg Sci & Adv Technol GF Ingrassia, Catania, Italy

[18] Univ Tubingen, Inst Archaeol Sci, Dept Geosci, Archaeo & Palaeogenet, Tubingen, Germany

[19] Univ Tubingen, Senckenberg Ctr Human Evolut & Palaeoenvironm, Tubingen, Germany

来源：

COMMUNICATIONS BIOLOGY | 2025年 / 8卷 / 01期

关键词：

HEMOGLOBIN CONCENTRATION; SELECTIVE SWEEPS; GROWTH; EXPRESSION; TIBETAN; KINASE; LAMC2; ADAPTATION; MUTATIONS; GENETICS;

D O I：

10.1038/s42003-025-07813-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Convergent adaptations represent paradigmatic examples of the capacity of natural selection to influence organisms' biology. However, the possibility to investigate the genetic determinants underpinning convergent complex adaptive traits has been offered only recently by methods for inferring polygenic adaptations from genomic data. Relying on this approach, we demonstrate how high-altitude Andean human groups experienced pervasive selective events at angiogenic pathways, which resemble those previously attested for Himalayan populations despite partial convergence at the single-gene level was observed. This provides additional evidence for the drivers of convergent evolution of enhanced blood perfusion in populations exposed to hypobaric hypoxia for thousands of years.

引用

页数：10

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