Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies

被引：0
作者：
Ji, Yumeng [1 ]
Li, Baixue [1 ]
Lin, Rongjin [1 ]
Yuan, Jing [1 ]
Han, Yang [1 ]
Du, Yuping [1 ,2 ]
Zhao, Yang [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Affiliated Hosp 3, Guangdong Prov Clin Res Ctr Obstet & Gynecol, Dept Obstet & Gynecol,Dept Gynecol Oncol Res Off,G, Guangzhou, Peoples R China
[2] 63 Duobao Rd, Guangzhou, Guangdong, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2025年 / 23卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Super enhancer; Transcription regulatory; Cancer; Targeted therapy; DRIVEN TRANSCRIPTIONAL DEPENDENCIES; HISTONE DEACETYLASE INHIBITOR; PROSTATE-CANCER; CELL IDENTITY; SELECTIVE-INHIBITION; PHASE-SEPARATION; BET INHIBITORS; BRD4; EXPRESSION; MEDIATOR;
D O I：
10.1186/s12967-025-06098-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor samples, super enhancers have been identified as crucial players in the development and progression of tumor cells, opening up new avenues for cancer research and treatment. This review provides a concise overview of various models regarding super enhancer assembly and activation, examining the mechanisms through which tumor cells acquire or activate these enhancers and regulate carcinogenic transcription programs. Furthermore, we discuss the current landscape and challenges in developing cancer therapeutic drugs that target super enhancers.
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页数：17
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