The comprehensive review of eucalyptol: synthesis, metabolism, and therapeutic applications in disease treatment

Background Eucalyptol (1,8-cineole), a naturally occurring monoterpenoid compound, is ubiquitously distributed across plant, animal, and microbial organisms. This bioactive molecule demonstrates significant therapeutic potential for various neurological and respiratory disorders, including cancer, epilepsy, and tracheitis, attributable to its potent antioxidant, anti-inflammatory, and antimicrobial properties. Scope and thrust The present review systematically examines the biosynthetic pathways and metabolic routes of eucalyptol, while elucidating its molecular mechanisms underlying microbial inhibition. We comprehensively summarize its principal therapeutic pathways in major disease interventions, with particular emphasis on its multi-target pharmacological actions. Furthermore, this analysis addresses potential toxicological concerns associated with eucalyptol application and discusses emerging strategies utilizing biological agents for active enhancement. Conclusion and significance This comprehensive evaluation not only enhances our understanding of eucalyptol's therapeutic mechanisms but also provides critical insights for its development as a promising phytopharmaceutical agent in clinical practice.