Hydrogels Based on Pluronic F127 As Nicotinic Acid and Nicotinamide Delivery Systems

被引：0
|
作者：
Agafonov, M. A. [1 ]
Kustov, S. O. [1 ,2 ]
Nikitina, M. G. [1 ]
Terekhova, I. V. [1 ]
机构：
[1] Russian Acad Sci, GA Krestov Inst Solut Chem, Ivanovo 153045, Russia
[2] Ivanovo State Univ, Ivanovo 153025, Russia
来源：
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2024年 / 98卷 / 14期
基金：
俄罗斯科学基金会;
关键词：
hydrogel; Pluronic; nicotinic acid; nicotinamide; release; RELEASE; NIACIN; GELATION; SKIN; SOLUBILITY; MECHANISM;
D O I：
10.1134/S0036024424702753
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The structural and mechanical properties of hydrogels prepared from Pluronic F127 (20 wt %) are described and analyzed. The effects of nicotinic acid and nicotinamide (1 wt %) additions on the gelation process and the properties of Pluronic hydrogels are considered. The influence of the ionization state of nicotinic acid and nicotinamide molecules on interactions with the polymer matrix of the gel was studied by H-1 NMR spectroscopy. A kinetic study of the release and transmembrane transport of nicotinic acid and nicotinamide included in Pluronic hydrogels was performed. The influence of the acidity of the medium on the rate of release of drug compounds from hydrogels and on the transmembrane transfer was analyzed.
引用
收藏
页码：3250 / 3256
页数：7
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