Association between ultra-processed food consumption and inflammation: insights from the STANISLAS cohort

被引：2

作者：

Xia, Lea Lin Chun Hu ^{[1
]}

Girerd, Nicolas ^{[1
]}

Lamiral, Zohra ^{[1
]}

Duarte, Kevin ^{[1
]}

Merckle, Ludovic ^{[1
]}

Leroy, Celine ^{[1
]}

Nazare, Julie-Anne ^{[2
]}

van den Berghe, Laurie ^{[2
]}

Seconda, Louise ^{[2
]}

Hoge, Axelle ^{[3
]}

Guillaume, Michele ^{[3
]}

Laville, Martine ^{[2
]}

Rossignol, Patrick ^{[1
,4
,6
]}

Boivin, Jean-Marc ^{[1
,5
]}

Wagner, Sandra ^{[1
]}

机构：

[1] Univ Lorraine, Inst Lorrain Coeur & Vaisseaux Louis Mathieu, Ctr Invest Clin Plurithemat, Inserm CIC P 1433,Pierre Drouin,INSERM,CHRU Nancy, 4 Rue Morvan, F-54500 Vandoeuvre Les Nancy, France

[2] Univ Lyon, Univ Claude Bernard Lyon 1, Ctr Rech Nutr Humaine Rhone Alpes, CarMeN Lab,Hosp Civils Lyon,F CRIN FORCE Network, Lyon, France

[3] Univ Liege, Dept Sci Sante Publ, Liege, Belgium

[4] Princess Grace Hosp, Monaco Private Hemodialysis Ctr, Med & Nephrol Dialysis Dept, Monaco, Monaco

[5] Univ Lorraine, Dept Gen Med, Vandoeuvre Les Nancy, France

[6] M CRIN Monaco Clin Res Infrastruct Network, Monaco, Monaco

来源：

EUROPEAN JOURNAL OF NUTRITION | 2025年 / 64卷 / 02期

关键词：

Ultra-processed food; NOVA; Inflammation; Circulating protein; Olink; Fibroblast growth factor 19; C-REACTIVE PROTEIN; HEALTH; RISK; ALCOHOL; CYTOKINES; IMPACT; ADULTS; DIET; KIT;

D O I：

10.1007/s00394-025-03607-y

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

PurposeHigh consumption of ultra-processed food (UPF) is associated with an increased risk of developing chronic diseases. Inflammation may be one of the underlying mechanisms behind this association. However, only a limited number of studies have investigated the association between UPF consumption and a few selected inflammation biomarkers, yielding inconsistent results. This study aimed to assess the cross-sectional association between UPF consumption (as a whole and 10 sub-categories), and 78 circulating proteins related to inflammation.MethodsThe present study included 1594 adult participants from the STANISLAS cohort. UPF consumption was estimated using the NOVA classification, and linear regression models were used to assess their association with circulating proteins.ResultsUPFs accounted for 28% of the total energy intake and 5.7 servings on average per day. In the unadjusted model, 15 circulating proteins had a significant association with UPF consumption. After adjustment, only (FGF-19) was significantly associated with UPF consumption (beta = - 0.02[- 0.03; - 0.003]).ConclusionUPF consumption was negatively associated with Fibroblast Growth Factor 19 (FGF-19) serum levels. When considering UPF sub-categories, no circulating proteins were associated with dairy products and dairy desserts. Of note, circulating proteins were differentially associated depending on the sub-category of UPF. Further studies are needed to better understand the link between UPF and inflammation.

引用

页数：13

共 81 条

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