Multi-targeted pharmacological properties of cinnamyl piperazine derivatives: a comprehensive review

被引：0

作者：

Wang, Yongqi ^{[1
]}

Lei, Mengchen ^{[1
]}

Zhao, Zefeng ^{[1
]}

Wu, Shaoping ^{[2
]}

Zheng, Xiaohui ^{[2
]}

Qiao, Haifa ^{[1
]}

Yang, Xiaohang ^{[1
]}

机构：

[1] Shaanxi Univ Chinese Med, Xian, Shaanxi Provinc, Peoples R China

[2] Northwest Univ, Xian, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2025年 / 34卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cinnamyl piperazine; Derivatives; Bioactivity; Review; ADHESION MOLECULE-1 INTERACTION; P-ARYLTHIO CINNAMIDES; BIOLOGICAL EVALUATION; ACYL-COA; BENZYLIDENEMALONONITRILE TYRPHOSTINS; ACYLTRANSFERASE INHIBITOR; CINEPAZIDE MALEATE; POTENT INHIBITORS; EGF RECEPTOR; IN-VITRO;

D O I：

10.1007/s00044-024-03322-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cinnamyl piperazine motif is a crucial element in drugs targeting various biological targets. Medicinal chemistry researchers have designed and synthesized drug-like cinnamyl piperazine candidates with multiple medicinal properties, including activities in the central nervous system (CNS), antitumor, antiviral, anti-inflammatory, antimicrobial, cardiovascular, and enzyme inhibitory effects. Structure-activity relationship (SAR) investigations have been a focus for medicinal chemists, and several derivatives have been developed for different targets. In this article, we comprehensively summarize the biological activities and SAR of cinnamyl piperazine derivatives, as well as the notable clinical candidates reported in patents and the co-crystal structure between cinnamyl piperazine derivatives and potential targets, aiming to provide an overall retrospective and prospective view of cinnamyl piperazine analogs.

引用

页码：19 / 44

页数：26

共 100 条

[51] Synthesis and antiproliferative action of a novel series of maprotiline analogues [J].

McNamara, Y. M. ;

Bright, S. A. ;

Byrne, A. J. ;

Cloonan, S. M. ;

McCabe, T. ;

Williams, D. C. ;

Meegan, M. J. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 71 :333-353

[52] Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists [J].

Morley, RM ;

Tse, HW ;

Feng, BH ;

Miller, JC ;

Monaghan, DT ;

Jane, DE .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (07) :2627-2637

[53] Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors [J].

Ngo, Van T. H. ;

Van-Hai Hoang ;

Phuong-Thao Tran ;

Nguyen Van Manh ;

Ann, Jihyae ;

Kim, Eunhye ;

Cui, Minghua ;

Choi, Sun ;

Lee, Jiyoun ;

Kim, Hee ;

Ha, Hee-Jin ;

Choi, Kwanghyun ;

Kim, Young-Ho ;

Lee, Jeewoo .

BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (12) :3133-3144

[54] Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases [J].

Nitsche, Christoph ;

Steuer, Christian ;

Klein, Christian D. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (24) :7318-7337

[55] Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates [J].

O'Boyle, Niamh M. ;

Ana, Gloria ;

Kelly, Patrick M. ;

Nathwani, Seema M. ;

Noorani, Sara ;

Fayne, Darren ;

Bright, Sandra A. ;

Twamley, Brendan ;

Zisterer, Daniela M. ;

Meegan, Mary J. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 17 (25) :6184-6200

[56]

Ohishi K, 2003, BIOL PHARM BULL, V26, P1125

[57] Structure-activity relationships of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N′-(3,4-dimethylphenyl)piperazine and analogues as inhibitors of acyl-CoA:: Cholesterol O-acyltransferase [J].

Ohishi, K ;

Aiyama, R ;

Hatano, H ;

Yoshida, Y ;

Wada, Y ;

Yokoi, W ;

Sawada, H ;

Watanabe, T ;

Yokokura, T .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (07) :830-839

[58] Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides [J].

Pei, ZH ;

Xin, ZL ;

Liu, G ;

Li, YH ;

Reilly, EB ;

Lubbers, NL ;

Huth, JR ;

Link, JT ;

von Geldern, TW ;

Cox, BF ;

Leitza, S ;

Gao, Y ;

Marsh, KC ;

DeVries, P ;

Okasinski, GF .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (18) :2913-2920

[59] Discovery of Novel Protease Activated Receptors 1 Antagonists with Potent Antithrombotic Activity in Vivo [J].

Perez, Michel ;

Lamothe, Marie ;

Maraval, Catherine ;

Mirabel, Etienne ;

Loubat, Chantal ;

Planty, Bruno ;

Horn, Clemens ;

Michaux, Julien ;

Marrot, Sebastien ;

Letienne, Robert ;

Pignier, Christophe ;

Bocquet, Arnaud ;

Nadal-Wollbold, Florence ;

Cussac, Didier ;

de Vries, Luc ;

Le Grand, Bruno .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (19) :5826-5836

[60]

POURRIAS B, 1974, THERAPIE, V29, P43

← 1 2 3 4 5 6 7 8 9 10 →