Adaptive Self-Defense of Mature Cells against Damage Is Based on the Warburg Effect, Dedifferentiation of Cells, and Resistance to Cell Death

被引：0

作者：

P. M. Schwartsburd ^{[1
]}

机构：

[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Moscow oblast, Pushchino

来源：

Biophysics | 2024年 / 69卷 / 4期

关键词：

cell self-defense; dedifferentiation; Warburg effect;

D O I：

10.1134/S0006350924700751

中图分类号：

学科分类号：

摘要：

Abstract: This review analyzes the hypothesis of the preserved ability of various specialized mammalian cells to protect themselves from lethal injury by enacting a protective atavistic mechanism of cell dedifferentiation. The development of such a protection is accompanied by a transition of differentiated cells from the mitochondrial oxygen-dependent type of metabolism to reductive oxygen-independent metabolism (called the Warburg effect). This transition allows cells to increase the resistance to cell death from hypoxia, and can also induce the emergence of fetal markers characteristic of cell dedifferentiation. This paper, exemplified by the development of two pathologies (heart failure and type 2 diabetes), presents the findings that confirm the existence of such a mechanism and ways of its possible correction. © Pleiades Publishing, Inc. 2024.

引用

页码：667 / 673

页数：6

共 35 条

[1]

Guo Y., Wu W., Yang X., Fu X., Dedifferentiation and in vivo reprogramming of committed cells in wound repair, Mol. Med. Rep, 26, (2020)

[2]

Schwartsburd P.M., Aslanidi K.B., Hypoxic cancer cells protect themselves against damage: Search for a single-cell indicator of this protective response, Novel Approach in Cancer Study, 7, 4, (2023)

[3]

Warburg O., Wind F., Negelein E., The metabolism of tumours in the body, J. Gen. Physiol, 8, pp. 519-530, (1927)

[4]

Riester M., Xu Q., Moreira A., Zheng J., Michor F., Downey R., The Warburg effect: persistence of stem-cell metabolism in cancers as a failure of differentiation, Ann. Oncol, 29, pp. 264-270, (2018)

[5]

Serio S., Pagiatakis C., Musolina E., Felicetta A.,., Carullo P., Frances J.L., Papa L., Rozzi G., Salvarani N., Miragoli M., Gornati R., Bernardini G., Condorelli G., Papah R., Cardiac aging is promoted by pseudohypoxia increasing p300-induces glycolysis, Circ. Res, 133, pp. 686-703, (2023)

[6]

Williamson J.R., Chang K., Frangos M., Hasan K.S., Ido Y., Kawamura T., Nyengaard J.R., van den Enden M., Kilo C., Tilton R.G., Hyperglycemic pseudohypoxia and diabetic complications, Diabetes, 42, pp. 801-813, (1993)

[7]

Pecze L., Randi E.B., Szabo C., Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudo-hypoxic state in Down syndrome, Mol. Med, 26, (2020)

[8]

Salminen A., Kauppinen K., Kaarniranta K., Hypoxia/ischemia active processing of Amypoid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer’s disease, J. Neurochem, 140, pp. 536-549, (2017)

[9]

Go S., Kramer T.T., Verhoeven A.J., Oude Elferink R.P.J., Chang J.-C., The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD<sup>+</sup> redox state, Apoptosis, 26, pp. 38-51, (2020)

[10]

Gwangwa A., Joubert A.M., Visagise M.H., Crosstalk between Warburg effect, redox regulation and autophagia, Cell. Mol. Biol. Lett, 23, (2018)

← 1 2 3 4 →