Real-world data of perioperative complications in prepectoral implant-based breast reconstruction: a prospective cohort study

PurposeTo analyze complications and potential risk factors associated with immediate prepectoral direct-to-implant breast reconstruction (DTIBR). Methods295 patients (326 operated breasts) with DTIBR between March 2021 and December 2023 were included in this prospective study. Postoperative complications (postoperative bleeding, seroma, infection, necrosis, wound dehiscence, implant exchange/loss) were analyzed for potential risk factors by descriptive and logistic regression analyses. ResultsThe implant was covered by TiLOOP (R) Bra Pocket in 227 breasts (69.6%), by "dual-plane" technique in 20 breasts (6.1%), by acellular dermal matrix (ADM) in 1 breast (0.3%). No additional support was used for 78 breasts (23.9%). The use of mesh did not increase the risk for complications. Major complications requiring surgical revision occurred due to postoperative bleeding in 22 (6.7%), seroma in 2 (0.6%), infection in 13 (4.0%), necrosis in 10 (3.1%), and wound dehiscence in 10 (3.1%) breasts. Thirteen (4.0%) implants were exchanged, and 5 (1.5%) were explanted without substitution. One patient had to switch to autologous reconstruction due to skin necrosis. The main reasons for the removal/exchange of implants were infections (11 breasts, 3.4%) and necrosis (4 breasts, 1.2%). The risk for necrosis, infection, and wound dehiscence was mainly associated with the type of incision, especially skin-reducing incisions, and body mass index (BMI) >= 30 kg/m2. ConclusionSevere complications occurred primarily in patients with a BMI >= 30 kg/m2 and when skin-reducing surgical techniques were performed. Trial RegistryThis study was retrospectively registered at the German Clinical Trials Register (DRKS) on 20.06.2024. DRKS-ID: DRKS00034493. https://drks.de/search/de/trial/DRKS00034493.