Protective effect of methanol extract of mustard (Brassica juncea) seed on cisplatin-induced cardiotoxicity in rats

被引：0
作者：
Omowunmi Monisola Adefegha [1 ]
Adebowale Bernard Saba [2 ]
Olayinka Ayotunde Oridupa [2 ]
Bukola Oyebanji [2 ]
机构：
[1] Department of Animal Health and Production, Federal College of Agriculture, Ondo State, Akure
[2] Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Ibadan
[3] Department of Animal Sciences, Faculty of Agriculture, Obafemi Awolowo University, Ile Ife
来源：
Comparative Clinical Pathology | 2025年 / 34卷 / 1期
关键词：
Antioxidant; Cardiotoxicity; Cisplatin; Mustard seeds; Vitamin E;
D O I：
10.1007/s00580-024-03630-1
中图分类号：
学科分类号：
摘要：
Cisplatin (CIS) is a commonly used chemotherapy for the treatment of various forms of cancer. However, clinical evidence has shown that cardiotoxicity is associated with CIS and has limited its clinical use. This study is aimed at evaluating the effect of methanol extract of mustard (Brassica juncea) seed (MEMS) on CIS-induced cardiotoxicity in Rats. In an experiment that lasted 21 days, rats were grouped and administered normal saline or 100–200 mg/kg of MEMS or 25 mg/kg of vitamin E prior to a single intraperitoneal injection of 10 mg/kg of CIS. The levels of lipid peroxidation (LPO), total protein (TP), reduced glutathione (GSH), and non-protein thiol (NPSH), as well as the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT), were measured in the heart tissue of the experimental rats. Hematological analysis and histological examination were subsequently performed. CIS-induced rats had significantly higher LPO levels, but the level of NPSH, TP, and GSH and GPx, SOD, and CAT activities were significantly reduced. Co-administration with MEMS resulted into decreased LPO level, and significant elevation of SOD, CAT, and GPx activities and GSH levels. Furthermore, hematological changes and histopathological alterations caused by CIS-induced cardiotoxicity were ameliorated by MEMS administration. B. juncea seeds possess antioxidant effects against CIS-induced oxidative stress and changes in parameters of blood cells and cardiac structure in rats. Thus, MEMS could serve as a potential cardioprotective agent for reducing cardiac damage during CIS therapy. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2024.
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页码：119 / 131
页数：12
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