Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood-Brain Barrier Integrity

被引：0
作者：
de Rezende, Victoria Linden [1 ,2 ]
da Costa, Maiara de Aguiar
Martins, Carla Damasio [1 ,2 ]
Mathias, Khiany [1 ,2 ,3 ]
Goncalves, Cinara Ludvig [1 ,2 ]
Barichello, Tatiana [1 ,2 ,4 ]
Petronilho, Fabricia [1 ,2 ,5 ]
机构：
[1] Univ Southern St Catarina UNESC, Grad Program Hlth Sci, Lab Expt Neurol, Criciuma, SC, Brazil
[2] Univ South Santa Catarina, Grad Program Hlth Sci, Hlth Sci Unit, Lab Neurobiol Inflammatory & Metab Proc, Tubarao, SC, Brazil
[3] Univ South Santa Catarina, Grad Program Hlth Sci, Hlth Sci Unit, Lab Immunoparasitol, Tubarao, SC, Brazil
[4] Univ Texas Hlth Sci Ctr Houston UTHealth, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA
[5] Univ Extremo Sul Catarinense, Grad Program Hlth Sci, Lab Expt Neurol, BR-88806000 Criciuma, SC, Brazil
来源：
NEUROCHEMICAL RESEARCH | 2025年 / 50卷 / 02期
关键词：
Aging; Rejuvenating therapies; Neuroinflammation; Blood-brain-barrier; STEM-CELL TRANSPLANTATION; PLATELET-RICH PLASMA; CEREBROSPINAL-FLUID; HETEROCHRONIC PARABIOSIS; COGNITIVE FUNCTION; CALORIC RESTRICTION; MOUSE MODEL; AGE; MICROGLIA; YOUNG;
D O I：
10.1007/s11064-025-04361-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aging process results in structural, functional, and immunological changes in the brain, which contribute to cognitive decline and increase vulnerability to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and stroke-related complications. Aging leads to cognitive changes and also affect executive functions. Additionally, it causes neurogenic and neurochemical alterations, such as a decline in dopamine and acetylcholine levels, which also impact cognitive performance. The chronic inflammation caused by aging contributes to the impairment of the blood-brain barrier (BBB), contributing to the infiltration of immune cells and exacerbating neuronal damage. Therefore, rejuvenating therapies such as heterochronic parabiosis, cerebrospinal fluid (CSF) administration, plasma, platelet-rich plasma (PRP), and stem cell therapy have shown potential to reverse these changes, offering new perspectives in the treatment of age-related neurological diseases. This review focuses on highlighting the effects of rejuvenating interventions on neuroinflammation and the BBB.
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页数：15
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