Exosomal MiRNA Therapy for Central Nervous System Injury Diseases

被引：2
|
作者：
Chang, Cui [1 ]
Liang, Weiping [2 ]
Chen, Jibing [2 ]
机构：
[1] Guangxi Univ Chinese Med, 179 Mingxiu East Rd, Nanning 530001, Guangxi, Peoples R China
[2] Guangxi Univ Chinese Med, Ruikang Hosp, 10 Huadong Rd, Nanning 530011, Guangxi, Peoples R China
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2024年 / 45卷 / 01期
关键词：
MicroRNAs; Traumatic brain injury; Ischemic stroke; Intracerebral hemorrhage; Optic nerve injury; Spinal cord injury; MESENCHYMAL STEM-CELLS; TRAUMATIC BRAIN-INJURY; MICRORNA; CONTRIBUTES; RECOVERY; DELIVERY; INCREASE;
D O I：
10.1007/s10571-024-01522-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Central nervous system diseases include central nervous system injury diseases, neurodegenerative diseases, and other conditions. MicroRNAs (miRNAs) are important regulators of gene expression, with therapeutic potential in modulating genes, pathways, and cells associated with central nervous system injury diseases. This article comprehensively reviews the therapeutic role of exosomal miRNAs in various central nervous system injury diseases, including traumatic brain injury, ischemic stroke, intracerebral hemorrhage, optic nerve injury, and spinal cord injury. This review covers the pathophysiology, animal models, miRNA transfection, administration methods, behavioral tests for evaluating treatment efficacy, and the mechanisms of action of miRNA-based therapies. Finally, this article discusses the future directions of miRNA therapy for central nervous system injury diseases.
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页数：15
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