Exosomal MiRNA Therapy for Central Nervous System Injury Diseases

被引：3

作者：

Chang, Cui ^{[1
]}

Liang, Weiping ^{[2
]}

Chen, Jibing ^{[2
]}

机构：

[1] Guangxi Univ Chinese Med, 179 Mingxiu East Rd, Nanning 530001, Guangxi, Peoples R China

[2] Guangxi Univ Chinese Med, Ruikang Hosp, 10 Huadong Rd, Nanning 530011, Guangxi, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2024年 / 45卷 / 01期

关键词：

MicroRNAs; Traumatic brain injury; Ischemic stroke; Intracerebral hemorrhage; Optic nerve injury; Spinal cord injury; MESENCHYMAL STEM-CELLS; TRAUMATIC BRAIN-INJURY; MICRORNA; CONTRIBUTES; RECOVERY; DELIVERY; INCREASE;

D O I：

10.1007/s10571-024-01522-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Central nervous system diseases include central nervous system injury diseases, neurodegenerative diseases, and other conditions. MicroRNAs (miRNAs) are important regulators of gene expression, with therapeutic potential in modulating genes, pathways, and cells associated with central nervous system injury diseases. This article comprehensively reviews the therapeutic role of exosomal miRNAs in various central nervous system injury diseases, including traumatic brain injury, ischemic stroke, intracerebral hemorrhage, optic nerve injury, and spinal cord injury. This review covers the pathophysiology, animal models, miRNA transfection, administration methods, behavioral tests for evaluating treatment efficacy, and the mechanisms of action of miRNA-based therapies. Finally, this article discusses the future directions of miRNA therapy for central nervous system injury diseases.

引用

页数：15

共 62 条

[1] ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway [J].

Cai, Lin ;

Gong, Qiuyuan ;

Qi, Lin ;

Xu, Tongtong ;

Suo, Qian ;

Li, Xiang ;

Wang, Wei ;

Jing, Yao ;

Yang, Dianxu ;

Xu, Zhiming ;

Yuan, Fang ;

Tang, Yaohui ;

Yang, Guoyuan ;

Ding, Jun ;

Chen, Hao ;

Tian, Hengli .

CELL COMMUNICATION AND SIGNALING, 2022, 20 (01)

[2] Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5 [J].

Chang, Qing ;

Hao, Yupeng ;

Wang, Yifan ;

Zhou, Yingjie ;

Zhuo, Hanjie ;

Zhao, Gang .

BRAIN RESEARCH BULLETIN, 2021, 170 :199-210

[3] Neuronal over-expression of ACE2 protects brain from ischemia-induced damage [J].

Chen, Ji ;

Zhao, Yuhui ;

Chen, Shuzhen ;

Wang, Jinju ;

Xiao, Xiang ;

Ma, Xiaotang ;

Penchikala, Madhuri ;

Xia, Huijing ;

Lazartigues, Eric ;

Zhao, Bin ;

Chen, Yanfang .

NEUROPHARMACOLOGY, 2014, 79 :550-558

[4]

Chen YF, 2020, AGING-US, V12, P18274, DOI 10.18632/aging.103692

[5] Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury [J].

Chen, Yuyong ;

Tian, Zhenming ;

He, Lei ;

Liu, Can ;

Wang, Nangxiang ;

Rong, Limin ;

Liu, Bin .

STEM CELL RESEARCH & THERAPY, 2021, 12 (01)

[6] Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine [J].

Damasceno, Patricia Kauanna Fonseca ;

de Santana, Thais Alves ;

Santos, Girlaine Cafe ;

Orge, Iasmim Diniz ;

Silva, Daniela Nascimento ;

Albuquerque, Juliana Fonseca ;

Golinelli, Giulia ;

Grisendi, Giulia ;

Pinelli, Massimo ;

Ribeiro dos Santos, Ricardo ;

Dominici, Massimo ;

Soares, Milena Botelho Pereira .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8

[7] MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis [J].

Datta, Neha ;

Johnson, Charlotte ;

Kao, Dina ;

Gurnani, Pratik ;

Alexander, Cameron ;

Polytarchou, Christos ;

Monaghan, Tanya M. .

PHARMACOLOGICAL RESEARCH, 2023, 194

[8] Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2 [J].

Deng, Yiming ;

Chen, Duanduan ;

Gao, Feng ;

Lv, Hong ;

Zhang, Guojun ;

Sun, Xuan ;

Liu, Lian ;

Mo, Dapeng ;

Ma, Ning ;

Song, Ligang ;

Huo, Xiaochuan ;

Yan, Tianyi ;

Zhang, Jingbo ;

Miao, Zhongrong .

JOURNAL OF BIOLOGICAL ENGINEERING, 2019, 13 (01)

[9]

Duan SR, 2020, DRUG DES DEV THER, V14, P3143, DOI [10.2147/DDDT.S255828, 10.2147/DDDT.S255628]

[10] Exosomal microRNA in autoimmunity [J].

Duan, Weijia ;

Zhang, Weici ;

Jia, Jidong ;

Lu, Qianjin ;

Gershwin, M. Eric .

CELLULAR & MOLECULAR IMMUNOLOGY, 2019, 16 (12) :932-934

← 1 2 3 4 5 6 7 →