Synthesis, Biological Evaluation, and Computational Study of Novel 1,2,3-Triazole-Tethered Chalcone Derivatives

被引：1

作者：

Kawale, R. A. ^{[1
]}

Shaikh, M. H. ^{[2
]}

Akolkar, H. N. ^{[3
]}

Khedkar, V. M. ^{[4
]}

Raut, D. N. ^{[5
]}

Shelke, S. N. ^{[6
]}

机构：

[1] Arts Sci & Commerce Coll Mokhada, Dept Chem, Palghat 401604, Maharashtra, India

[2] Radhabai Kale Mahila Mahavidyalaya, Dept Chem, Ahmednagar 414001, Maharashtra, India

[3] Abasaheb Marathe Arts & New Commerce Sci Coll Raja, Dept Chem, Ratnagiri 416702, Maharashtra, India

[4] Vishwakarma Univ, Sch Pharm, Pune 411048, Maharashtra, India

[5] Amrutvahini Coll Pharm, Sangamner 422605, Maharashtra, India

[6] RB Narayanrao Borawake Coll, Dept Chem, Shrirampur 413709, Maharashtra, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 09期

关键词：

1,2,3-triazoles; molecular docking; anti-inflammatory activity; antioxidant activity; chalcone; computational study; TRIAZOLE-LINKED CHALCONE; CYTOTOXIC EVALUATION; MOLECULAR DOCKING; ACCURATE DOCKING; ANTIOXIDANT; DESIGN; GLIDE; DISCOVERY;

D O I：

10.1134/S1070428024090161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In search of novel anti-inflammatory and antioxidant agents with improved potency, a small focused library of 1,2,3-triazole-based chalcone derivatives has been efficiently prepared via the click chemistry approach. All synthesized compounds' Structures were characterized with the help of IR, H-1 NMR, C-13 NMR, and mass spectroscopic techniques. All the synthesized novel derivatives were evaluated for their anti-inflammatory activity. Molecular docking studies against COX-2 gave valuable insights into the mechanistic basis of the demonstrated anti-inflammatory activity. Further, the synthesized compounds were found to have potential antioxidant activity.

引用

页码：1730 / 1743

页数：14

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