Research advances in the construction of stem cell-derived ovarian organoids

被引：0
作者：
Tianyue Zhang [1 ]
Mengtong Zhang [2 ]
Sichen Zhang [1 ]
Shaowei Wang [1 ]
机构：
[1] Department of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing
[2] Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
来源：
Stem Cell Research & Therapy | / 15卷 / 1期
关键词：
Decellularization; Extracellular matrix; Ovarian organoid; Pluripotent stem cells; Synthetic matrices;
D O I：
10.1186/s13287-024-04122-3
中图分类号：
学科分类号：
摘要：
Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and improving treatments, which benefits women’s health. Constructing ovarian organoids involves two main processes: differentiating induced pluripotent stem cells (iPSCs) into germ and ovarian somatic cells to restore ovarian function and using extracellular matrix (ECM) to create a suitable ovarian microenvironment and scaffold. Although the technology is still in its early stages, future advancements will likely involve integrating high-throughput analysis, 3D-printed scaffolds, and efficient iPSC induction, driving progress in reproductive and regenerative medicine. © The Author(s) 2024.
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