From Mechanisms to Management: Tackling In-Stent Restenosis in the Drug-Eluting Stent Era

被引：1

作者：

Spadafora, Luigi ^{[1
]}

Quarta, Rossella ^{[2
,4
]}

Martino, Giovanni ^{[3
]}

Romano, Letizia ^{[3
,4
]}

Greco, Francesco ^{[5
]}

Curcio, Antonio ^{[2
,4
]}

Gori, Tommaso ^{[3
,6
,7
]}

Spaccarotella, Carmen ^{[8
]}

Indolfi, Ciro ^{[2
]}

Polimeni, Alberto ^{[2
,5
]}

机构：

[1] Sapienza Univ Rome, Dept Med & Surg Sci & Biotechnol, Latina, Italy

[2] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[3] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Div Cardiol, I-88100 Catanzaro, Italy

[4] Annunziata Hosp, Div Cardiol, I-87100 Cosenza, Italy

[5] Annunziata Hosp, Div Intervent Cardiol, I-87100 Cosenza, Italy

[6] Univ Med Ctr Mainz, Kardiol 1, Zentrum Kardiol, Standort Rhein Main, Germany

[7] DZHK Standort Rhein Main, Mainz, Germany

[8] Univ Naples Federico II, Dept Adv Biomed Sci, Div Cardiol, I-80126 Naples, Italy

来源：

CURRENT CARDIOLOGY REPORTS | 2025年 / 27卷 / 01期

关键词：

Percutaneous coronary interventions; coronary stent; in-stent restenosis; DES; OPTICAL COHERENCE TOMOGRAPHY; PERCUTANEOUS CORONARY INTERVENTION; COATED BALLOON ANGIOPLASTY; MUSCLE-CELL-PROLIFERATION; GAMMA-RADIATION THERAPY; OF-THE-ART; INTRAVASCULAR LITHOTRIPSY; CLINICAL-OUTCOMES; ANGIOGRAPHIC RESTENOSIS; NEOINTIMAL HYPERPLASIA;

D O I：

10.1007/s11886-025-02193-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewDrug-eluting stent (DES) technology has greatly enhanced the safety and effectiveness of percutaneous coronary interventions (PCI). The aim of the present paper is to provide a comprehensive review of in-stent restenosis (ISR), focusing on the contemporary DES era, including its incidence, mechanisms, and imaging characterization.Recent findingsDespite the widespread use of DES and numerous improvements, recent clinical data indicate that ISR still occurs in 5-10% of PCI procedures, posing a considerable public health issue.SummaryThe incidence, morphology, and clinical implications of ISR are determined by a complex interplay of several factors: the patient, stent, procedure, and vessel and lesion-related factors. Advancements in intracoronary imaging have provided greater insight into its patterns and underlying causes. Over time, treatment strategies have evolved, and current guidelines recommend an individualized approach using intracoronary imaging to characterize ISR's underlying substrate.

引用

页数：20

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