SASS6 promotes tumor proliferation and is associated with TP53 and immune infiltration in lung adenocarcinoma

被引：0
作者：
Li, Zihao [1 ]
He, Lingyun [1 ]
Li, Jiayi [2 ]
Qian, Jing [3 ]
Wu, Zuotao [3 ]
Zhu, Yongjie [3 ]
Zhuo, Ting [4 ]
Nong, Jusen [5 ]
Liang, Honghua [1 ]
Zheng, Hua [1 ]
Huang, Weijia [1 ]
Huang, Julu [6 ]
Cao, Jianbin [1 ]
机构：
[1] Guangxi Med Univ, Liuzhou Peoples Hosp, Dept Thorac Surg, Liuzhou, Guangxi, Peoples R China
[2] Guangxi Med Univ, Liuzhou Peoples Hosp, Dept Nephrol, Liuzhou, Guangxi, Peoples R China
[3] Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Nanning, Guangxi, Peoples R China
[4] Guangxi Med Univ, Affiliated Hosp 1, Dept Resp Med, Nanning, Guangxi, Peoples R China
[5] Guangxi Med Univ, Affiliated Hosp 1, Dept Pediat Surg, Nanning, Guangxi, Peoples R China
[6] Guangxi Med Univ, Liuzhou Peoples Hosp, Dept Med Oncol, Liuzhou, Guangxi, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL MEDICINE | 2024年 / 24卷 / 01期
关键词：
Cell cycle; Immune infiltration; Lung adenocarcinoma; Prognosis; SASS6; CENTROSOME AMPLIFICATION; CHROMOSOME INSTABILITY; CANCER; AFATINIB; ABNORMALITIES; GEFITINIB; ERLOTINIB; MUTATION; CERNA; CELLS;
D O I：
10.1007/s10238-024-01510-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The most common type of non-small cell lung cancer is lung adenocarcinoma (LUAD), which is characterized by high morbidity and poor survival. Up-regulation of SASS6 expression can lead to the progression of various malignant tumors. However, there are no relevant studies on the role of SASS6 in LUAD. SASS6 was highly expressed in most tumors, reflecting a good diagnostic value, and its overexpression in LUAD indicated discouraging overall prognosis. Functional enrichment analysis suggested that SASS6 was associated with cell cycle in LUAD. In addition, patients with high SASS6 expression had worse immune infiltration, but higher TMB and immune checkpoint, and higher sensitivity to multiple targeted drugs such as osimertinib. Cell experiments confirmed that knockdown of SASS6 could inhibit the viability of tumor cells.SASS6 has important value in the diagnosis of cancer. In particular, SASS6 is a crucial factor in the progression of LUAD, and has important clinical value, especially in the diagnosis, prognosis and treatment
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页数：16
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