Impact of baseline genetic profile and treatment on outcome and hematological toxicity in CEBPA-mutated AML

被引:0
作者
Mannelli, Francesco [1 ,2 ,3 ]
Piccini, Matteo [2 ]
Frigeni, Marco [4 ]
Gianfaldoni, Giacomo [2 ]
Bencini, Sara [5 ]
Salmoiraghi, Silvia [4 ]
Scappini, Barbara [2 ]
Peruzzi, Benedetta [5 ]
Caporale, Roberto [5 ]
Ciolli, Gaia [1 ,2 ]
Crupi, Francesca [1 ,2 ,3 ]
Fasano, Laura [1 ,2 ]
Quinti, Elisa [1 ,2 ]
Pasquini, Andrea [1 ,2 ]
Caroprese, Jessica [1 ,2 ,3 ]
Vanderwert, Fiorenza [2 ,3 ]
Rotunno, Giada [2 ,3 ]
Pancani, Fabiana [2 ,3 ]
Signori, Leonardo [1 ,2 ,3 ]
Tarantino, Danilo [2 ,3 ]
Maccari, Chiara [2 ,3 ]
Annunziato, Francesco [1 ,5 ]
Spinelli, Orietta [4 ]
Guglielmelli, Paola [1 ,2 ,3 ]
Rambaldi, Alessandro [4 ,6 ]
Vannucchi, Alessandro M. [1 ,2 ,3 ]
机构
[1] Univ Firenze, Dipartimento Med Sperimentale & Clin, Florence, Italy
[2] Univ Firenze, SOD Ematol, AOU Careggi, Florence, Italy
[3] Ctr Ric & Innovaz Malattie Mieloproliferat CRIMM, AOU Careggi, Florence, Italy
[4] Azienda Socio Sanit Territoriale ASST Osped Papa G, Bergamo, Italy
[5] Ctr Diagnost Citofluorimetria & Immunoterapia, AOU Careggi, Florence, Italy
[6] Univ Milan, Dept Oncol & Hematol, Milan, Italy
来源
BLOOD CANCER JOURNAL | 2025年 / 15卷 / 01期
关键词
ACUTE MYELOID-LEUKEMIA; GATA2; MUTATIONS;
D O I
10.1038/s41408-025-01224-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:4
相关论文
共 18 条
  • [1] Long-term follow-up of cytogenetically normal CEBPA-mutated AML
    Pastore, Friederike
    Kling, Daniela
    Hoster, Eva
    Dufour, Annika
    Konstandin, Nikola P.
    Schneider, Stephanie
    Sauerland, Maria C.
    Berdel, Wolfgang E.
    Buechner, Thomas
    Woermann, Bernhard
    Braess, Jan
    Hiddemann, Wolfgang
    Spiekermann, Karsten
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2014, 7
  • [2] The role of different genetic subtypes of CEBPA mutated AML
    Fasan, A.
    Haferlach, C.
    Alpermann, T.
    Jeromin, S.
    Grossmann, V.
    Eder, C.
    Weissmann, S.
    Dicker, F.
    Kohlmann, A.
    Schindela, S.
    Kern, W.
    Haferlach, T.
    Schnittger, S.
    LEUKEMIA, 2014, 28 (04) : 794 - 803
  • [3] CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex
    Schmidt, Luisa
    Heyes, Elizabeth
    Scheiblecker, Lisa
    Eder, Thomas
    Volpe, Giacomo
    Frampton, Jon
    Nerlov, Claus
    Valent, Peter
    Grembecka, Jolanta
    Grebien, Florian
    LEUKEMIA, 2019, 33 (07) : 1608 - 1619
  • [4] Long-term follow-up of cytogenetically normal CEBPA-mutated AML
    Friederike Pastore
    Daniela Kling
    Eva Hoster
    Annika Dufour
    Nikola P Konstandin
    Stephanie Schneider
    Maria C Sauerland
    Wolfgang E Berdel
    Thomas Buechner
    Bernhard Woermann
    Jan Braess
    Wolfgang Hiddemann
    Karsten Spiekermann
    Journal of Hematology & Oncology, 7
  • [5] Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity
    Bacher, Ulrike
    Schnittger, Susanne
    Macijewski, Katja
    Grossmann, Vera
    Kohlmann, Alexander
    Alpermann, Tamara
    Kowarsch, Andreas
    Nadarajah, Niroshan
    Kern, Wolfgang
    Haferlach, Claudia
    Haferlach, Torsten
    BLOOD, 2012, 119 (20) : 4719 - 4722
  • [6] Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA-mutated AML
    Heyes, Elizabeth
    Schmidt, Luisa
    Manhart, Gabriele
    Eder, Thomas
    Proietti, Ludovica
    Grebien, Florian
    LEUKEMIA, 2021, 35 (09) : 2526 - 2538
  • [7] Frequency and clinical impact of WT1 mutations in the context of CEBPA-mutated acute myeloid leukemia
    Wang, Ting
    Hua, Haiying
    Wang, Zheng
    Wang, Biao
    Cao, Liujun
    Qin, Wei
    Wu, Pin
    Cai, Xiaohui
    Chao, Hongying
    Lu, XuZhang
    HEMATOLOGY, 2022, 27 (01) : 994 - 1002
  • [8] Impact of Genetic Features on Treatment Decisions in AML
    Doehner, Hartmut
    Gaidzik, Verena I.
    HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2011, : 36 - 42
  • [9] Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity
    Taskesen, Erdogan
    Bullinger, Lars
    Corbacioglu, Andrea
    Sanders, Mathijs A.
    Erpelinck, Claudia A. J.
    Wouters, Bas J.
    van der Poel-van de Luytgaarde, Sonja C.
    Damm, Frederik
    Krauter, Juergen
    Ganser, Arnold
    Schlenk, Richard F.
    Lowenberg, Bob
    Delwel, Ruud
    Doehner, Hartmut
    Valk, Peter J. M.
    Doehner, Konstanze
    BLOOD, 2011, 117 (08) : 2469 - 2475
  • [10] Variable outcome and methylation status according to CEBPA mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment
    El-Sharkawi, Dima
    Sproul, Duncan
    Allen, Christopher G.
    Feber, Andrew
    Wright, Melissa
    Hills, Robert K.
    Linch, David C.
    Gale, Rosemary E.
    HAEMATOLOGICA, 2018, 103 (01) : 91 - 100