Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke

被引：3

作者：

Ahmadzadeh, Amir Mahmoud ^{[1
,2
]}

Pourbagher-Shahri, Ali Mohammad ^{[3
]}

Forouzanfar, Fatemeh ^{[3
,4
]}

机构：

[1] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Radiol, Mashhad, Iran

[3] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Sch Med, Mashhad, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Neurosci, Mashhad, Iran

来源：

INFLAMMOPHARMACOLOGY | 2025年

关键词：

Medicinal plants; Ischemic stroke; Autophagy; Complementary medicine; Polyphenols; Carotenoids; CEREBRAL ISCHEMIA/REPERFUSION INJURY; REPERFUSION INJURY; INDUCED APOPTOSIS; GINSENOSIDE RB1; MEDIATED AUTOPHAGY; ASTRAGALOSIDE IV; OXIDATIVE STRESS; CELL-DEATH; MECHANISMS; BRAIN;

D O I：

10.1007/s10787-024-01606-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stroke is a serious life-threatening medical condition. Understanding the underlying molecular mechanisms of this condition is crucial to identifying novel therapeutic targets that can improve patient outcomes. Autophagy is an essential mechanism for the destruction of damaged intracellular components that maintains homeostasis in physiological or pathological conditions. This process is involved in the pathophysiology of stroke. Phytochemicals are bioactive naturally occurring compounds present in plants. This paper reviews the neuroprotective roles of phytochemicals in ischemic stroke through autophagy modulation. It summarizes the interactions of various phytochemicals with key molecular targets of the autophagy pathway in ischemic stroke, including PI3K/Akt/mTOR, Beclin-1, and AMPK. Due to the ability of various phytochemicals to alter autophagic flux, they may provide promising opportunities in the development of new treatments and the improvement of stroke management.

引用

页码：729 / 757

页数：29

共 153 条

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